Revised issue of Margaret of Austria from my
Margareta domina TL.
Margaret of Austria, Duchess of Burgundy (b. January 1480, r. from 1496) m. Philibert II, Duke of Savoy (b. 1480, r. from 1504) in 1497, had issue
1) Mary (b. September 1498) m. John III, King of Castile, Aragon, and Portugal (b. 1498)
2) Philip V, Duke of Burgundy (b. April 1500) m. Katherine Tudor (b. 1503)
3) Margaret (b. February 1502) m. Christian II, King of Denmark, Sweden, and Norway (b. 1481)
4) Charles V, Holy Roman Emperor (b. August 1503) m. Elisabeth Jagiellonica (b. 1505)
5) Philiberta (b. October 1505) m. Stephen VI Jagiellon, King of Hungary and Bohemia (b. 1504)
6) Bianca (b. March 1507) m. Massimiliano II Sforza, Duke of Milan (b. 1512)
Note:
Stephen and Elisabeth Jagiellon are the children of Vladislaus II and Maria of Aragon.
Beatriz and John are the children of Manuel I and Juana of Castile.
Massimiliano is the son of Francesco II Sforza and Bona Sforza.
Descendants of the Catholic Monarchs for this same timeline...
Isabella I, Queen of Castile (b. 1451, r. from 1474, d. 1507) m. Ferdinand II, King of Aragon (b. 1453, r. from 1479) in 1469, has issue
1) Isabel of Aragon and Castile, Princess of Portugal (b. 1470, d. 1503) m. Afonso, Prince of Portugal (b. 1475, d. 1491) in 1490, had no issue
2) Juan of Aragon and Castile, Prince of Asturias and Girona (b. 1478, d. 1497) m. Giovanna of Naples (b. 1478, d. 1518) in 1497, had no issue
3) Juana of Aragon and Castile, Queen of Portugal (b. 1479, d. 1555) m. Manuel I, King of Portugal (b. 1469, d. 1525) in 1497, had issue
1) John III, King of Portugal, Castile, and Aragon (b. 1498) m. Mary of Burgundy-Savoy (b. 1498)
2) Afonso of Portugal (b. 1500, d. 1502)
3) Beatriz of Portugal, Queen of Navarre (b. 1501) m. Henry II, King of Navarre (b. 1503)
4) Fernando, Duke of Viseu (b. 1503) m. Guiomar Coutinho, 5th Countess of Marialva and 3rd Countess of Loulé (b. 1510)
5) Isabel of Portugal, Queen of France (b. 1505) m. Charles IX, King of France (b. 1501)
6) Pedro of Portugal (b. and d. 1507)
7) Henrique of Portugal, Cardinal and Archbishop of Braga and Évora (b. 1509)
8) Duarte of Portugal, Duke of Guimarães (b. 1512) m. Isabel of Braganza (b. 1514)
4) Maria of Aragon and Castile, Queen of Hungary and Bohemia (twin of stillborn child; b. 1482, d. 1542) m. Vladislaus II, King of Hungary and Bohemia (b. 1456, d. 1516) in 1502, had issue
1) Stephen VI Jagiellon, King of Hungary and Bohemia (b. 1504)
2) Elisabeth Jagiellonica (b. 1505)
3) Louis Jagiellon, Duke of Slavonia (b. 1507, d. 1528)
4) Andrew Jagiellon, Cardinal and Archbishop of Veszprém (b. 1509)
5) Ladislaus Jagiellon (b. and d. 1513)
6) Anna Jagiellonica (b. and d. 1516)
5) Stillborn child (twin of Maria; b. and d. 1482)
6) Catalina of Aragon and Castile, Princess of Wales (b. 1485) m. Arthur Tudor, Prince of Wales (b. 1486) in 1502, has issue
1) Elizabeth Tudor (b. 1505, d. 1506)
2) Henry Tudor (b. and d. 1507)
3) Margaret Tudor (b. and d. 1508)
4) Edward VI Tudor (twin of Edmund; b. 1510) m. Jeanne/Isabeau of Brittany (b. 1510)
5) Edmund Tudor, Duke of Richmond (twin of Edward; b. 1510, d. 1533)
6) Mary Tudor, Duchess of Lorraine (b. 1512) m. Francis I, Duke of Lorraine (b. 1517) (a); Adrian Stokes (b. 1519) (b)