Dom Teodósio, Duke of Braganza and Prince of Brazil, eldest son and heir of João IV of Portugal, survives his OTL death in 1653.
Teodósio I, King of Portugal (b. 1634, r. 1656-1691, d. 1691) m. Catherine Beatrice of Savoy (b. 1636, d. 1684) [1] in 1657, had issue
1. Infanta Maria Beatriz of Portugal, Queen of England, Scotland, and Ireland (b. 1658, d. 1718) m. James II, King of England, Scotland, and Ireland (b. 1633, r. 1685-1688, d. 1701) in 1673, had issue
1. Catherine Anne Stuart (b. and d. 1675)
2. Isabel/Isabella Stuart (b. 1676, d. 1681)
3. Charles Stuart, Duke of Cambridge (b. and d. 1677)
4. Charlotte Henrietta Stuart (b. and d. 1682)
5. Louisa Mary Stuart, Princess of Orange (b. 1688, d. 1765) m. John William Friso, Prince of Orange (b. 1687, d. 1711) in 1709, had issue
6. James Edward Charles Stuart, Titular King of England, Scotland, and Ireland (b. 1692, d. 1712) unmarried but had illegitimate issue
2. Infante João of Portugal, Prince of Brazil (b. 1660, d. 1663)
3. Infante Luís of Portugal, Duke of Barcelos (b. and d. 1662)
4. Infanta Teodósia Maria of Portugal, Princess of Biera (b. 1664, d. 1733) unmarried, no issue
5. Pedro II, King of Portugal (b. 1666, r. 1691-1724, d. 1724) m. Maria Sophia of Neuburg (Maria Sophie Elisabeth; b. 1666, d. 1699) in 1687, had issue
1. Infante João of Portugal, Prince of Biera (João Carlos Francisco António Xavier de Paula Domingos Miguel Gabriel Rafael; b. and d. 1688)
2. João V, King of Portugal (João Francisco António José Bento Bernardo; b. 1689, d. 1750) m. Maria Anna of Austria (Maria Anna Josepha Antonia Regina; b. 1683, d. 1754) in 1708, had issue
3. Infante Francisco of Portugal, Duke of Beja (Francisco Xavier José António Bento Urbano; b. 1691, d. 1742) unmarried but had illegitimate issue
4. Infante Antonio of Portugal (António Francisco Xavier Benedito Teodósio Leopoldo Henrique; b. 1695, d. 1757) unmarried but had illegitimate issue
5. Infanta Teresa Maria of Portugal (b. 1696, d. 1704)
6. Infante Manuel of Portugal, Count of Ourém (Manuel José Francisco António Caetano Estêvão Bartolomeu; b. 1697, d. 1766)
7. Infanta Francisca Josefa (Francisca Josepha Maria Xaviera; b. 1699, d. 1736)
6. Infanta Luísa Adelaide of Portugal, Duchess of Brunswick-Lüneburg (b. 1667, d. 1725) m. Maximilian Wilhelm, Duke of Brunswick-Lüneburg (b. 1666, d. 1726) in 1692, had no issue
7. Infante Afonso of Portugal, Duke of Barcelos (b. 1669, d. 1675)
8. Infanta Henriqueta Cristina of Portugal, Duchess of Modena (b. 1671, d. 1710) m. Rinaldo d’Este, Duke of Modena (b. 1655, d. 1737) in 1696, had issue
1. Catarina Maria d’Este (b. 1697, d. 1777)
2. Francesco III d’Este, Duke of Modena (b. 1698, d. 1780) m. Charlotte Aglaé d’Orléans (b. 1700, d. 1761) in 1720, had issue
3. Amalia Beatrice d’Este, Marquise of Villeneuf (b. 1699, d. 1778) m. the Marquis de Villeneuf (b. and d. unknown)
4. Gian Teodosio d’Este (b. 1700, d. 1727)
5. Enrichetta d’Este (b. 1702, d. 1777) m. Antonio Farnese, Duke of Parma (b. 1679, d. 1731) in 1728, had no issue (a); Leopold of Hesse-Darmstadt (b. Unknown, d. 1764) in 1740, had no issue (b)
6. Clemente d'Este (b. and d. 1708)
7. Stillborn daughter (b. and d. 1710)
9. Infante Diogo of Portugal, Duke of Barcelos (b. 1674, d. 1722) unmarried, no issue
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[1] Twin of Henriette Adelaide of Savoy, Electress of Bavaria, OTL she died in infancy.