POD: Gender-swapped Catherine of Aragon.
Ferdinand II of Aragon (1452-1516) m. Isabella of Castille (1451-1506)
- Isabella(1470-1509) m. Afonso VI of Portugal (1475-1518)
- Isabella(1492-1545) m. Charles IX of France (1492-1523) [1]
- Charles X of France (1509-1568) m. a) Margaret of Austria (1510-1539), b) Elisabeth of Austria (1525-1592)
- Anne (1511-1556) m. James V of Scotland (1507-1544) [2]
- Isabella (1512-1568) m. Casimir V of Poland (1494-1549) [3]
- Charlotte (1514-1522)
- Francis III of Brittany (1516-1564) m. Joan of Lorraine (1516-1571)
- Louis (1517)
- Madeleine (1519-1580) m. Arthur I of England (1520-1586)
- John, Duke of Anjou (1521-1577) m. Anne Stewart, Countess of Auvergne (1519-1583) [4]
- Philip, Duke of Valois (1523-1585) m. Catherine of Bourbon (1525-1594)
- John III of Portugal(1494-1552) m. Mary Tudor (1496-1543)
- Isabella (1512-1581) m. John III of Spain (1509-1577)
- Eleanor (1514-1548) m. Philibert III, Duke of Savoy (1503-1559)
- Afonso VII of Portugal (1515-1570) m. Catherine of Spain (1514-1569)
- Joanna (1517-1520)
- Maria (1521-1575) m. Manuel, Duke of Viseu and Beja (1523-1589)
- Henry (1523)
- Eleanor (1495)
- Afonso, Duke of Viseu and Beja (1498-1526) m. Beatrice, Duchess of Viseu and Beja (1501-1567) [6]
- Stillborn son (1518)
- Isabella (1520-1582) m. Ludovico II Sforza, Duke of Milan (1518-1566) [7]
- Manuel, Duke of Viseu and Beja (1523-1589) m. Maria of Portugal (1521-1575)
- John, Prince of Asturias and Girona (1478-1497) m. Margaret of Austria (1480-1530)
- Stillborn daughter (1498)
- Joanna(1479-1555) m. Philip, Duke of Burgundy (1478-1511)
- Eleanor(1498-1558) m. Antoine, Duke of Lorraine (1489-1544)
- Joan (1516-1571) m. Francis III of Brittany (1516-1564)
- Nicholas III of Lorraine (1518-1587) m. Amalia of Cleves (1517-1586)
- Stillborn son (1520)
- Charles (1523-1524)
- Philippa (1525-1585) m. Edward, Duke of York (1524-1583)
- Charles V, Holy Roman Emperor(1500-1561) m. Elizabeth Tudor (1504-1552)
- Stillborn daughter (1521)
- Philip (1522-1526)
- Stillborn son (1524)
- Maria (1525)
- Joanna (1527-1528)
- Stillborn son (1528)
- Charles VI, Holy Roman Emperor (1530-1599) m. Maria of Austria (1530-1597)
- Margaret (1532-1533)
- Stillborn daughter (1535)
- Maximilian (1501)
- Isabella (1504-1570) m. Henry VIII of England (1502-1561)
- See under Henry VIII of England.
- Ernest, Archduke of Inner Austria and King of Hungary, Croatia and Bohemia(1506-1554) m. Anna of Bohemia and Hungary (1503-1559)
- Elisabeth (1525-1592) m. Charles X of France (1509-1568)
- Anna (1526-1549) m. William, Duke of Jülich-Cleves-Berg (1516-1592)
- Maximilian, King of Hungary, Croatia and Bohemia (1528-1604) m. Hedwig of Poland (1531-1600) [8]
- Maria (1530-1597) m. Charles VI, Holy Roman Emperor (1530-1599)
- Charles (1531)
- Ernest, Archduke of Inner Austria (1533-1601) m. Margaret of Savoy (1538-1609) [9]
- Joanna (1534-1563) m. Frederick II of Denmark (1529-1578) [10]
- Catherine (1536-1602) nun
- Magdalena (1538-1541)
- Eleanor (1539-1595) m. Guglielmo Gonzaga, Duke of Mantua (1538-1587)
- Margaret (1541-1608) nun
- John (1543-1549)
- Barbara (1545-1602) m. Ferdinand IV of Naples (1541-1610)
- Mary(1507-1579) m. a) Louis II of Hungary (1506-1526), b) Alexander, Grand Duke of Lithuania (1497-1532) [11]
- a) Vladislaus (1525)
- b) Stillborn daughter (1529)
- b) Helena (1531-1595) m. John II of Poland (1530-1578) [8]
- Margaret(1510-1539) m. Charles X of France (1509-1568)
- Stillborn son (1528)
- Charles, Dauphin of France (1530-1538)
- Isabella (1532-1533)
- Stillborn daughter (1535)
- Louis XII of France (1537-1602) m. Anna Maria of Spain (1534-1590)
- Joan (1538-1600) m. Afonso, Prince of Portugal (1538-1560)
- Maria(1482-1531) m. Arthur, Prince of Wales (1486-1505)
- Henry VIII of England(1502-1561) m. Isabella of Austria (1504-1570)
- Arthur I of England (1520-1586) m. Madeleine of France (1519-1580)
- Henry (1522)
- Mary (1524-1529)
- Edward, Duke of York (1524-1583) m. Philippa of Lorraine (1525-1585)
- John (1527-1528)
- Elizabeth (1531-1588) m. Alexander IV of Scotland (1533-1601) [12]
- Elizabeth(1504-1552) m. Charles V, Holy Roman Emperor (1500-1561)
- See under Charles V, Holy Roman Emperor.
- Stillborn daughter (1482)
- Ferdinand VI of Spain(1485-1536) m. Anne of Navarre (1492-1530) [13]
- John III of Spain(1509-1577) m. Isabella of Portugal (1512-1581)
- Ferdinand, Prince of Asturias (1529-1545)
- John IV of Spain (1532-1609) m. Magdalene of England (1537-1605) [14]
- Anna Maria (1534-1590) m. Louis XII of France (1537-1602)
- Isabella (1546-1608) m. Charles Philibert, Duke of Savoy (1540-1591) [9]
- Isabella (1512-1513)
- Catherine(1514-1569) m. Afonso VII of Portugal (1515-1570)
- John (1532)
- Stillborn daughter (1534)
- Stillborn son (1535)
- Afonso, Prince of Portugal (1538-1560) m. Joan of France (1538-1600)
- Stillborn daughter (1540)
- Maria (1542-1604) m. Edward VI of England (1540-1616) [14]
- Anna (1543)
- Duarte (1546-1547)
- Ferdinand (1517)
- Maria (1519-1520)
- Anna(1523-1556) m. Ferdinand III of Naples (1521-1589)
- Joanna (1540)
- Ferdinand IV of Naples (1541-1610) m. Barbara of Austria (1545-1602)
- Alfonso (1543-1545)
- Isabella (1544-1593) m. Francesco II Sforza, Duke of Milan (1540-1597) [16]
- Maria (1546-1619) m. Ercole III, Duke of Ferrara (1543-1596) [17]
- John (1549-1550)
- Catherine (1551)
- Frederick (1552-1618) Cardinal
- Stillborn son (1554)
- Beatrice (1556-1607) m. Philip, Archduke of Tyrol (1552-1598) [18]
- Bianca (1556-1584) nun
[1] Surviving Charles Orlando. Charles VIII has his otl death. Anne of Brittany becomes regent of France and doesn't remarry.
[2] Son of James IV of Scotland and Margaret Tudor. Died young otl.
[3] Son of John I Albert of Poland and Kunigunde of Austria.
[4] Daughter of John Stewart, Duke of Albany and Anne de la Tour d'Auvergne.
[5] Son of Philibert II of Savoy and Margaret of Austria.
[6] Daughter and heiress of Manuel, Duke of Viseu and Beja (otl king of Portugal).
[7] Son of Massimiliano Sforza, Duke of Milan and Bona Sforza.
[8] Children of Isabella of France and Casimir V of Poland.
[9] Children of Philibert III of Savoy and Eleanor of Portugal.
[10] ATL son of Christian III of Denmark, who isn't a protestant ITTL.
[11] Son of Alexander I of Poland, who is only Grand Duke of Lithuania ITTL, and Helena of Moscow.
[12] Son of James V of Scotland and Anne of France.
[13] Is not a dwarf ITTL.
[14] Children of Arthur I of England and Madeleine of France.
[15] Grandson of Ferdinand II of Naples and Joanna of Naples.
[16] Son of Ludovico II Sforza and Isabella of Viseu.
[17] ATL son of Ercole II, Duke of Ferrara.
[18] Second son of Charles VI and Maria of Austria.