Papal dispensation will be required (as daughter 1 is half-aunt of son 1) and I think you have either make some mistake or daughter 1 is likely too old for marrying son 1
Would it not be a comparable case to the marriage between Ferdinand II and Germaine of Foix? IIRC, no papal-dispensation was needed there.
There's only a 7 year age difference. She'd be 29 while he'd be 22.