My guess is that Hughes will be blamed for "profiteers" at least as much as Wislon was--maybe more so, since the GOP was associated with big business more than the Democrats were.
Wlison though seems to have been spectacularly unprepared for dealing with the post-war economic problems.
From The Harding Era, Warren G. Harding and His Administration by Robert K. Murray.
"The Wilson Administration was woefully ill prepared to handle these normal stresses of demobilizaiton, let alone the much more complicated economic and social readjustments necessitated by the end of the war. Wilson had no one to blame but himself. As early as October 1917, he had been urged to create a reconstruction commission to study postwar problems, but he considered the time not yet ripe for such a move."-pg. 72
"By December 1918 President Wilson accepted the fact that his administration had no postwar plans. He even justified that condition. In his December message to Congress, just before departing for Versailles to make postwar plans for the entire world, he remarked that as far as the domestic American scene was concerned the American people would make their own reconstruction plans and "any leading strings we might seek to put them in would speedily become hopelessly tangled because they would pay no attention to them and go their own way."-pg. 73
"In the absence of any postwar blueprint the whole wartime regulatory structure quickly collapsed."-pg. 73
And even before his stroke post-war President Wilson seems to have been almost entirely disengaged with domestic matters and to have very little in the way of ideas to deal with the economic problems.
From The Harding Era, Warren G. Harding and His Administration by Robert K. Murray.
"His mind was so preoccupied with League maters that the government drifted aimlessly befor the sea of postwar problems that threatened to engulf it. Only intermittenly did Wilson turn his attention to domestic issues and then he dealt with them hurriedly before plunging back into the League struggle."-pg. 75
From Woodrow Wilson, A Biography by John Milton Cooper, Jr.
"The president seemed removed from the racial violence as well as other serious domestic problems, such as a rash of strikes, unemployment, inflation, and the continuing anti-rafical crusade that would culiminate in a full-fledeged Red scare at the end of the year."-pg. 510
"He had resumed cabinet meetings, and on July 31 the discussion for the first time dealt exclusively with troubles at home: inflation and another threatned railroad strike. Inflation, which had earned the initials HCL (for "the high cost of living," was particularly troubling, and the Republicans were trying to reap partisan gain from it. In response, Wilson spoke to a joint session of Congress on August 8. As with the speech to the Senate a month earlier, this one gave him great trouble in writing, and his delivery was rambling and disorganized. Substantively, aside from vigorous enforcement of laws and the dissemination of economic information, he had little to recommend: 'We must, I think, freely admit that there is no complete immediate rememdy from legislation and executive action.' He digressed with a description of the destruction wrought by the war, he attempted to link problems at home with delay in ratifying the peace treaty, and he delivered vague injunctions."-pg. 511
Now I don't know if Hughes would have ultimately been any more effective at dealing with all the post-war economic problems than Wilson was. (The post-war economic disruption is likely beyond the ability of any President to effectively manage.) But Hughes could hardly do worse at preparing for the post-war economy than Wilson did, and Hughes certainly won't get bogged down fighting over the League like Wilson did and presumably won't have Wilson's health issues, so Hughes will have a lot more time and energy to devote to domestic matter than Wilson did. If Hughes at least looks like he is seriously trying to solve the domestic problems then that might be enough to give him a fighting chance come 1920 since the Democrats themselves are pretty divided at this time.