A factor with the P-38 that has been mentioned is that it is a big airplane and can be seen, and readily identified from a long range. While a poorly trained pilot is cruising with long range tanks, and notices that he is being bounced, he is required to perform a dozen odd tasks, hitting the correct switches, not all visible, while shivering with cold, with heavily gloved hands and frost-bitten fingers, before he pushes the throttle forward and takes evasive action. Life could be better heated and pressurized, with some automation.
Can't be overstated. How dreadful and dangerous those flights must have been. Also there is the problem of hypothermia. Even mild hypothermia will dull the mind and reduce alertness. With TTLs' P-38 the position of the Prestone radiators a few inches from the cockpit and the new less drafty canopy should lead we would hope to an earlier and more effective cockpit heating solution that shouldn't require a great deal of engineering.