Ferdinand II, King of Aragon and Sicily (1452-1516) married Isabella I, Queen of Castile (1451-1510) in 1469
Maximilian I, Holy Roman Emperor (1459-1519) marry a) Mary, Duchess of Burgundy (1457-1482) in 1477 b) Anne of Brittany (1477-1514) in 1490 (annulled 1492) c) Bianca Maria Sforza (1472-1510) in 1493
Manuel I, King of Portugal (1469-1521) married a) Isabella, Princess of Asturias and Girona (1470-1498) in 1497, b) Joanna of Aragon-Naples (b. 1479) in 1501
- Isabella, Princess of Asturias and Girona (1470-1498), married a) Alfonso, Prince of Portugal (1475-1491) in 1490 and b) Manuel I, King of Portugal (1469-1519) in 1497
- b) Miguel da Paz, King of Spain (b. 1498) married Madeleine, Queen of Navarre (b. 1494) in 1512
- John III, King of Spain (b.1515) married a) Madeleine of France (1520-1540) in 1536, b) Beatrice of England (b. 1524) in 1541 with issue by both
- Isabella of Spain (1517-1544) married Francis III, Duke of Brittany (1518-1539) in 1533 with issue
- Catherine of Spain (b.1519) married John II, King of Denmark, Sweden and Norway (b.1518) with issue
- stillborn son (1522)
- Ferdinand (1524-1530)
- Beatrice of Spain (b. 1526), twin of Eleanor, married Charles IX, King of France (b. 1528) in 1542 with issue
- Eleanor of Spain (b. 1526), twin of Beatrice, married Henry IX, King of England (b. 1422) in 1540 with issue
- Alfonso of Spain (b. 1529) married Isabella of Guimarães (b. 1530)
- b) Miguel da Paz, King of Spain (b. 1498) married Madeleine, Queen of Navarre (b. 1494) in 1512
- miscarried son (1472)
- Juan, Prince of Asturias and Girona (1478-1497) married Margaret of Austria-Burgundy (b.1480) in 1497
- stillborn daughter (1497)
- Juana of Aragon (b.1479) married Philip IV, Duke of Burgundy (1478-1503) in 1496 with issue
- Beatriz of Aragon (1482) twin of Maria, stillborn
- Maria of Aragon (1482-1520) married Vladislaus II, King of Hungary and Bohemia (1469-1517) in 1501
- Elizabeth of Bohemia and Hungary (b. 1503) married Maximilian II, Holy Roman Emperor (b. 1503) with issue
- John of Bohemia and Hungary (1505-1510)
- Stephen VI, King of Bohemia and Hungary (1507-1526) married Mary of Savoy (b. 1505) without issue
- Hedwig of Bohemia and Hungary (1508-1510)
- Casimir of Bohemia and Hungary (1511-1514)
- Catalina of Aragon (1485-1518) married a) Arthur Tudor, Prince of Wales (1486-1502) in 1501 and b) Henry VIII, King of England (b.1491) in 1505
- b) miscarriage (1508)
- b) stillborn son (1509)
- b) Henry, Prince of Wales (1511)
- b) Isabella (1512)
- b) stillborn daughter (1514)
- b) Mary (1516-1520)
- b) miscarried daughter (1518)
Maximilian I, Holy Roman Emperor (1459-1519) marry a) Mary, Duchess of Burgundy (1457-1482) in 1477 b) Anne of Brittany (1477-1514) in 1490 (annulled 1492) c) Bianca Maria Sforza (1472-1510) in 1493
- a) Philip IV, Duke of Burgundy (1478-1503), married Joanna of Aragon (b.1479) in 1496
- Eleanor of Austria (b.1498) married Antoine, Duke of Lorraine (b. 1489) in 1512
- Nicholas (1514-1520)
- miscarriage (1515)
- Charles (1516-1520)
- Eleanor, Duchess of Lorraine (b.1518) married Ernest I, Holy Roman Emperor (b.1520) with issue
- Francis (1520)
- Mary (1522-1535)
- Charles V, Holy Roman Emperor (1500-1531) married a) Mary Tudor (1496-1523) in 1515 b) Isabella of Portugal (1509-1530) in 1524
- a) Philip, Count of Charolais (1518-1520)
- a) John of Austria (1520)
- a) stillborn daughter (1521)
- a) Joanna (1523-1528)
- b) Mary (1526)
- b) Isabella (1528-1530)
- b) Maximilian (1530)
- Isabella of Austria (b.1501) married Christian II, King of Denmark, Sweden and Norway (b.1481-1521) in 1514
- John II, King of Denmark, Sweden and Norway (b.1518) married Catherine of Spain (b.1519) with issue
- Philip Ferdinand (1419)
- Maximilian (1419)
- Dorothea (b.1520)
- Christina (b.1521) married Francis II, Duke of Milan (b.1518) with issue
- Maximilian II, Holy Roman Emperor (b.1503) married Elizabeth of Bohemia and Hungary (b.1503) in 1515
- Ernest I, Holy Roman Emperor (b. 1520) married Eleanor, Duchess of Lorraine (b.1518) with issue
- Maximilian I, King of Hungary and Poland (b.1521) married Elizabeth of Poland (b. 1522) with issue
- Elizabeth (b. 1524)
- Joanna (1525-1532)
- Charles (b. 1527), Grandmaster of Teutonic Order
- Eleanor (b. 1530)
- Frederick (1530-1539)
- Philip (1535)
- Anna (1538-1546)
- Margaret (1540)
- Helena (b. 1542)
- Rudolf (1545-1554)
- Magdalena (b. 1547)
- Eleanor of Austria (b.1498) married Antoine, Duke of Lorraine (b. 1489) in 1512
- a) Margaret of Austria-Burgundy (b. 1480) married a) John, Prince of Asturias and Girona (1478-1497) in 1497 b) Philibert II, Duke of Savoy (b. 1480) in 1501
- a) stillborn daughter (1498)
- b) Margaret of Savoy (b. 1502) married Sigismund I, King of Poland (b.1467) in 1516
- Hedwig of Poland (1519)
- stillborn son (1520)
- Elizabeth of Poland (b. 1522) married Maximilian I, King of Poland and Hungary (b. 1521) with issue
- Sigismund of Poland (1523-1538) died unmarried
- Anna of Poland (1525-1526)
- Sofia of Poland (b. 1528)
- miscarriage (1530)
- b) stillborn son (1503)
- b) Mary of Savoy (b. 1505) married a) Stephen VI, King of Bohemia and Hungary (1507-1526) in 1515 (consummated 1522) without issue b) Francis I, King of France (b. 1494) in 1526 with issue
- b) Maximilian I, Duke of Savoy (b. 1507) married Beatrice of Portugal (b. 1507) in 1522 with issue
- b) Charles of Savoy (b. 1509)
- a) Francis of Austria (1481)
Manuel I, King of Portugal (1469-1521) married a) Isabella, Princess of Asturias and Girona (1470-1498) in 1497, b) Joanna of Aragon-Naples (b. 1479) in 1501
- a) Miguel da Paz, King of Spain (b. 1498) married Madeleine, Queen of Navarre (b. 1494) in 1512 with issue
- b) Joanna of Portugal (b. 1503) married Henry VIII, King of England (b. 1491) in 1519 with issue
- Elizabeth of England (b. 1520) married James V, King of Scotland (b. 1512) in 1536 with issue
- Henry IX, King of England (b. 1522) married Eleanor of Spain (b.1526) in 1540 with issue
- Joanna of England (b. 1524) married William, Duke of Jülich-Cleves-Berg (b. 1514) in 1539 with issue
- Beatrice of England (b. 1527) married John III, King of Spain (b. 1514) in 1541 with issue
- Edward, Duke of York (b. 1531) married Anne Percy (b. 1531) with issue
- b) Ferdinand, Duke of Viseu (b. 1505) married Isabella of Braganza, Duchess of Guimarães (b. 1514) with issue
- b) Beatrice of Portugal (b. 1507) married Maximilian I, Duke of Savoy (b. 1507) in 1522 with issue
- b) Isabella of Portugal (b. 1508) married Charles V, Holy Roman Emperor (b. 1500) in 1524 with issue
- b) John, Duke of Beja (b. 1510) married Guiomar Coutinho (b. 1510) with issue
- b) Louis of Portugal, Duke of Guarda (1512-1519)
- b) Alfonso of Portugal (b. 1513), cardinal
- b) Henry of Portugal (1515-1516)
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