So how will this new Spain deal with the Ottomans?
They will fight them, specially in Africa but more in general in the Mediterranean and will also support the Polish Habsburgs (who rule Hungary) against them.

Venice will be clearly an important player in the anti-Ottomans alliance (meaning who Genoa will have closer alliance with the Austrian Habsburg, while Venice will be allied with Avis Spain and the Polish Habsburgs)
 
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They will fight them, specially in Africa but more in general in the Mediterranean and will also support the Polish Habsburgs (who rule Hungary) against them.

Venice will be clearly an important player in the anti-Ottomans alliance (meaning who Genoa will have closer alliance with the Austrian Habsburg, while Venice will be allied with Avis Spain and the Polish Habsburgs)
Do the Austrian and Polish Habsburgs really hate each other?
 
Do the Austrian and Polish Habsburgs really hate each other?
Not really, they helped each other, if the other need it, but had simply different focus (Germany and Northern Italy for the Austrian branch, Eastern Europe and Balkans for the Polish one). When Spain need to go against France its usual allies are Austrian Habsburgs and Milan plus some of Genoa, Savoy. Ferrara and Mantua who usually switch alliances)
 
@TickTock The Witch's Dead : looking at what I had already wrote (and forgotten) looks like who Genoa will be in the French camp, lose badly some war and will be divided between Spain (who will take Corsica) and Milan (who will take the former republic as part of its domains, getting a sea access)
 
Try to guess who will need to rework practically all the trees as is now persuaded who the match between Manuel and Maria in this scenario is extremely unlikely?
 
Ferdinand II, King of Aragon and Sicily (1452-1516) married Isabella I, Queen of Castile (1451-1510) in 1469
  1. Isabella, Princess of Asturias and Girona (1470-1498), married a) Alfonso, Prince of Portugal (1475-1491) in 1490 and b) Manuel I, King of Portugal (1469-1519) in 1497
    1. b) Miguel da Paz, King of Spain (1498-1530) married Madeleine, Queen of Navarre (1494-1529) in 1512
      1. John III, King of Spain (b.1515) married a) Madeleine of France (1520-1540) in 1536, b) Beatrice of England (b. 1528) in 1541 with issue by both
      2. Isabella of Spain (1517-1544) married Francis III, Duke of Brittany (1518-1539) in 1533 with issue
      3. Catherine of Spain (b.1519) married John II, King of Denmark, Sweden and Norway (b.1518) with issue
      4. stillborn son (1522)
      5. Ferdinand (1524-1530)
      6. Beatrice of Spain (b. 1526), twin of Eleanor, married Charles IX, King of France (b. 1528) in 1542 with issue
      7. Eleanor of Spain (b. 1526), twin of Beatrice, married Henry IX, King of England (b. 1422) in 1540 with issue
      8. Alfonso of Spain (b. 1529) married Isabella of Guimarães (b. 1530)
  2. miscarried son (1472)
  3. Juan, Prince of Asturias and Girona (1478-1497) married Margaret of Austria-Burgundy (b.1480) in 1497
    1. stillborn daughter (1497)​
  4. Juana of Aragon (b.1479) married Philip IV, Duke of Burgundy (1478-1503) in 1496 with issue
  5. Beatriz of Aragon (1482) twin of Maria, stillborn
  6. Maria of Aragon (1482-1520) Vladislaus II, King of Hungary and Bohemia (1469-1517) in 1501
    1. Elizabeth of Bohemia and Hungary (b. 1503) married Maximilian II, Holy Roman Emperor (b. 1503) with issue
    2. John of Bohemia and Hungary (1505-1510)
    3. Stephen VI, King of Bohemia and Hungary (1507-1526) married Mary of Savoy (b. 1505) without issue
    4. Hedwig of Bohemia and Hungary (1508-1510)
    5. Casimir of Bohemia and Hungary (1511-1514)
  7. Catalina of Aragon (1485-1518) married a) Arthur Tudor, Prince of Wales (1486-1502) in 1501 and b) Henry VIII, King of England (b.1491) in 1505
    1. b) miscarriage (1508)
    2. b) stillborn son (1509)
    3. b) Henry, Prince of Wales (1511)
    4. b) Isabella (1512)
    5. b) stillborn daughter (1514)
    6. b) Mary (1516-1520)
    7. b) miscarried daughter (1518)

Maximilian I, Holy Roman Emperor (1459-1519) marry a) Mary, Duchess of Burgundy (1457-1482) in 1477 b) Anne of Brittany (1477-1514) in 1490 (annulled 1492) c) Bianca Maria Sforza (1472-1510) in 1493
  1. a) Philip IV, Duke of Burgundy (1478-1503), married Joanna of Aragon (b.1479) in 1496
    1. Eleanor of Austria (b.1498) married Antoine, Duke of Lorraine (b. 1489) in 1512
      1. Nicholas (1514-1520)
      2. miscarriage (1515)
      3. Charles (1516-1520)
      4. Eleanor, Duchess of Lorraine (b.1518) married Ernest I, Holy Roman Emperor (b.1520) with issue
      5. Francis (1520)
      6. Mary (1522-1535)
    2. Charles V, Holy Roman Emperor (1500-1531) married a) Mary Tudor (1496-1523) in 1515 b) Isabella of Portugal (1509-1530) in 1524
      1. a) Philip, Count of Charolais (1518-1520)
      2. a) John of Austria (1520)
      3. a) stillborn daughter (1521)
      4. a) Joanna (1523-1528)
      5. b) Mary (1526)
      6. b) Isabella (1528-1530)
      7. b) Maximilian (1530)
    3. Isabella of Austria (b.1501) married Christian II, King of Denmark, Sweden and Norway (b.1481-1521) in 1514
      1. John II, King of Denmark, Sweden and Norway (b.1518) married Catherine of Spain (b.1519) with issue
      2. Philip Ferdinand (1419)
      3. Maximilian (1419)
      4. Dorothea (b.1520)
      5. Christina (b.1521) married Francis II, Duke of Milan (b.1518) with issue
    4. Maximilian II, Holy Roman Emperor (b.1503) married Elizabeth of Bohemia and Hungary (b.1503) in 1515
      1. Ernest I, Holy Roman Emperor (b. 1520) married Eleanor, Duchess of Lorraine (b.1518) with issue
      2. Maximilian I, King of Hungary and Poland (b.1521) married Elizabeth of Poland (b. 1520) with issue
      3. Elizabeth (b.1524)
      4. Joanna (1525-1532)
      5. Charles (b.1527), Grandmaster of Teutonic Order
      6. Eleanor (b.1530)
      7. Frederick (1530-1539)
      8. Philip (1535)
      9. Anna (1538-1546)
      10. Margaret (1540)
      11. Helena (b.1542)
      12. Rudolf (1545-1554)
      13. Magdalena (b.1547)
  2. a) Margaret of Austria-Burgundy (b. 1480) married a) John, Prince of Asturias and Girona (1478-1497) in 1497 b) Philibert II, Duke of Savoy (b. 1480) in 1501
    1. a) stillborn daughter (1498)
    2. b) Eleanor of Savoy (b. 1502) married Sigismund I, King of Poland (b.1467) in 1516
      1. Elizabeth of Poland (b. 1520) married Maximilian I, King of Poland and Hungary (b. 1521) with issue
      2. stillborn son (1521)
      3. Sigismund of Poland (1523-1538) died unmarried
      4. Anna of Poland (1525-1526)
      5. Sofia of Poland (b. 1528)
      6. miscarriage (1530)
    3. b) stillborn son (1503)
    4. b) Mary of Savoy (b. 1505) married a) Stephen VI, King of Bohemia and Hungary (1507-1526) in 1515 (consummated 1522) without issue b) Francis I, King of France (b. 1494) in 1526 with issue
    5. b) Maximilian I, Duke of Savoy (b. 1507) married Beatrice of Portugal (b. 1507) in 1522 with issue
    6. b) Charles of Savoy (b. 1508)
  3. a) Francis of Austria (1481)

Manuel I, King of Portugal (1469-1521) married a) Isabella, Princess of Asturias and Girona (1470-1498) in 1497, b) Joanna of Aragon-Naples (b. 1479) in 1501
  1. a) Miguel da Paz, King of Spain (b. 1498) married Madeleine, Queen of Navarre (b. 1494) in 1512 with issue
  2. b) Joanna of Portugal (b. 1503) married Henry VIII, King of England (b. 1491) in 1519 with issue
    1. Elizabeth of England (b. 1520) married James V, King of Scotland (b. 1512) in 1536 with issue
    2. Henry IX, King of England (b. 1522) married Eleanor of Spain (b.1526) in 1540 with issue
    3. Joanna of England (b. 1524) married William, Duke of Jülich-Cleves-Berg (b. 1514) in 1539 with issue
    4. Beatrice of England (b. 1528) married John III, King of Spain (b. 1514) in 1541 with issue
    5. Edward, Duke of York (b. 1531) married Anne Percy (b. 1531) with issue
  3. b) Ferdinand, Duke of Viseu (b. 1505) married Isabella of Braganza, Duchess of Guimarães (b. 1514) with issue
  4. b) Beatrice of Portugal (b. 1507) married Maximilian I, Duke of Savoy (b. 1507) in 1522 with issue
  5. b) Isabella of Portugal (b. 1508) married Charles V, Holy Roman Emperor (b. 1500) in 1524 with issue
  6. b) John, Duke of Beja (b. 1510) married Guiomar Coutinho (b. 1510) with issue
  7. b) Louis of Portugal, Duke of Guarda (1512-1519)
  8. b) Alfonso of Portugal (b. 1513), cardinal
  9. b) Henry of Portugal (1515-1516)
Updated… luckily without too many troubles…
 
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