What if, for some reason, Spain never conquers the Aztecs or Inca? (Most likely POD, Cortez dying, and no conquistadors come for some ASB reason), and the Spanish never gains the Large amount of New World wealth of Gold and Silver?

There can be those countries who can still get rich off of trading. Maybe a Columbian Exchange, that isn't violent as OTL, but trading, rather than conquest with the Mesoamericans and Inca. At first, it be the Spanish trading, than the Portuguese, the Dutch, the English and the French.

The Mesoamericans and the Inca continue to exists, but the Spain never gains the mines of Silver and Gold. And without this large wealth of silver and gold, how would taking that large wealth away, effect Europe and Asia?
 
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