I wasn't sure where to put this as all the PoDs are pre-1900 but the meat of the question is post-1900.
Duke of Edinburgh murdered by asylum-escapee - (1868).
Fenian sniper kills Arthur, Duke of Connaught at Battle of Eccles Hill - (1870).
Heir to throne Prince Albert Edward dies of typhoid - (1871).
Prince Leopold, Duke of Albany dies of haemophilia aged 26 - (1880).
Prince George and Prince Albert Victor die of typhoid - (1892).
All of these events are semi-OTL. DofE was shot by a madman in Australia. Connaught wasn't shot but apparently did fight at that battle, the three typhoids are OTL, but Albert (Edward VII) and George recovered while Albert Victor died. Leopold has died here 4 years early, so the issue of issue is an issue.
What happens now?
The eldest descendant of Queen Victoria is...
...Queen Victoria. Of Prussia. Queen Mother to Kaiser Wilhelm II.
Queen Victoria dies in January 1901 and leaves her will declaring Victoria of Prussia or Wilhelm (of whom she was very fond) her heir. If former, Victoria of Prussia dies in August 1901 as OTL.
Duke of Edinburgh murdered by asylum-escapee - (1868).
Fenian sniper kills Arthur, Duke of Connaught at Battle of Eccles Hill - (1870).
Heir to throne Prince Albert Edward dies of typhoid - (1871).
Prince Leopold, Duke of Albany dies of haemophilia aged 26 - (1880).
Prince George and Prince Albert Victor die of typhoid - (1892).
All of these events are semi-OTL. DofE was shot by a madman in Australia. Connaught wasn't shot but apparently did fight at that battle, the three typhoids are OTL, but Albert (Edward VII) and George recovered while Albert Victor died. Leopold has died here 4 years early, so the issue of issue is an issue.
What happens now?
The eldest descendant of Queen Victoria is...
...Queen Victoria. Of Prussia. Queen Mother to Kaiser Wilhelm II.
Queen Victoria dies in January 1901 and leaves her will declaring Victoria of Prussia or Wilhelm (of whom she was very fond) her heir. If former, Victoria of Prussia dies in August 1901 as OTL.