In addition, there's a third sister Victoria, who'd be 3 at the time.
By 1892, when George & Eddy bite the dust, IOTL Louise was already married to the Duke of Fife and, depending on butterflies, already have a one-year-old daughter Alexandra (they also had a stillborn son in 1890, but given the butterflies, Louise & Fife could have completely different kids). Toria, who was a spinster IOTL because Queen Alexandra insisted on keeping her as a companion, likely gets married to secure the succession.
The only chance one of Willy's descendants ends up on the British throne is as a consort to Louise's kids, either Victoria Louise (or an ATL sister) if Louise has a surviving son ITTL, or one of the younger boys for her OTL eldest daughter Alexandra. Even that is unlikely as at the time of the marriage Queen Victoria, the biggest cheerleader for the match, is dead and their Danish grandmother is alive and won't allow that marriage over her dead body. Alexandra of Denmark (and Edward VII) despised Willy, and to her, the German kids are the spawn of Prussia (who stole Schleswig Holstein from Denmark) and the German family that took over the Schleswig Holstein title. The Wales girls will be pretty deferential to their parents, dad died young and thus lives on in eternal nostalgia, and mom was the only one there and already over-protective IOTL. If Alix tells her daughters "Don't to marry off my sweet grandchildren to dirty Prussians, especially Willy's children, who your late father disliked" the wedding won't happen.
They're much more likely to get married to a different cousin if Louise only has girls the best choice might be a non-hemophiliac son of Princess Beatrice and Henry of Battenburg (either Alexander or Maurice). They're close in age, related, and (importantly for Alexandra) German in name only, and even then they come from a morganatic Hessian branch, and Hesse hated Prussia as much as Denmark did. They're basically the male equivalents of Mary of Teck: fathers born of morganatic marriages, mothers British princesses, and both raised in Britain. If the heir's a boy (say a surviving Alistair of Fife, probably named Albert Edward ITTL for his late maternal grandfather), Alexandra likely pushes for one of her nieces or a descendant of Princess Alice (Hesse was one of the few acceptable German houses to Alice, especially because the Hesse girls were raised by Queen Victoria,). Options include Dagmar of Denmark (Alexandra's Danish niece), Marie or Stephanie of Schaumberg Lippe (grand-nieces of Alexandra), Margaretha of Sweden (another grand-niece of Alexandra), Louise of Battenberg (Grandaughter of Princess Alice, IOTL Queen of Sweden & Aunt of Prince Philip, Duke of Edinburgh).