Sometimes mankind comes up with something that makes God, the number serial killer in all of history, cry.
Then there are times that God is seriously considering having another flood just to clean house.
Occasionally God just says "Fuck it." And decides to leave humanity to their own devices for a few years (examples include: The Destruction of Atlantis, The Dark Ages, Hitler's Rise to Power, and Flashpants)
Further still God has once or twice decided to wipe everything out on the entire planet, first it was the Wood Nymphs from Planet 9 and then the Dinosaurs.
But then God looks upon the verdant green world he created for his most beloved children, humanity, and find something so sick, twisted, and vile that even Satan-nay-even Karl Rove would not take it down into the deep dank depths of Hell, a.k.a. Baltimore.
When God finds that he is at least comforted that it cannot be as profoundly idiotic as this piece of crap.