Thing is because they had Canada, and Washington - the capital - is located further north and very close to NYC more attention was placed to the Great Lakes area earlier. Baltimore probably also suffered as a consequence. And without D.C. being a link between Philly and Richmond, Richmond is likely much more an isolate of an urban area than in OTL. Rather than a BosWash corridor, I'd say its MontPhilly in TTL.
On the brighter note, without a Civil War, Richmond has likely retained quite a bit of its Southern character.
The important border towns, I'm guessing, are likely farther West, by the rivers where shipping would be more important. Whatever is in the Ohio/Mississippi confluence here is likely big and important. As is anything along Tennessee River, on both sides.
This probably wouldn't be so if so much of the South hadn't left the US (if the rest of the Upper South had stayed, Richmond and Baltimore probably would've fared better than ITTL, as at least there'd be something to counterbalance having the capital so far north).
And for what it's worth, I think of most of the Richmond area as STILL mostly Southern in nature in OTL especially when compared to NoVA or (arguably) the Norfolk/VA Beach area. I agree though that the "Little Egypt" area of the US would see greater importance in terms of trade; there, as well as Kentucky and Virginia, would probably be seen as "Southern-in-nature" the same way the Great Lakes states are IOTL when compared to Canada (it really is remarkable how much Great Lakes Americans and Canadians in general have in common, as they sound similar, enjoy similar sports, eat similar cuisine styles, etc. I imagine the border states of the US, especially the ones of the "Old South", would have a similar relationship with the DSA).