I believe that the current evidence strongly supports human over-hunting as the cause of the megafauna extinctions. From a
this post on the thread, A Bad Day Off East Africa-Around 3 Million Yrs Ago:
I do agree that humans were almost certainly responsible for the successive waves of extinctions that coincided with their first appearances in new territories. One particularly compelling bit of evidence concerns the North American mammoths. There had always been a debate over whether the primary cause of their extinction had been human over-hunting or the climate changing from glacial to interglacial conditions. I had always had my doubts about climate change, since the glaciers had retreated dozens of times before without significant elevations of the rate of extinctions, so why the huge increase on the first interglacial that included humans?
But recently the debate has been definitively resolved (in my opinion). A study has looked at the bone structure, and the population demographics, of the most recent mammoth fossils. The two scenarios under consideration would lead to very different evidence. If the culprit was climate change and resulting lack of food resources, then you would expect to see poor bone structure with evidence of numerous periods of malnutrition. You would also expect to see few infants, as the birth rate would plummet to conserve the mothers' resources, in a typical response to famine conditions. On the other hand, if over-hunting was the primary culprit, you would expect to see good bone structure, since there would be plenty of food for the few surviving mammoths, and many infants, as the population would be producing new members as quickly as possible to replace the numerous deaths from hunting.
So what to we see in the fossil record at the end of the time of mammoths? Good bone structure and many infant and young mammoths. Combined with the fact that this was also the beginning of human occupation of North America, and it's a settled case to me. Humans over-hunted the mammoths to extinction.
I recall reading somewhere that they may have died off from a combination of mass mammoth-plague and over-hunting. Something about their teeth, I can't remember the specifics right now.
Anyway, let us all take a look at some of the friendly faces that might be encountered ITTL:
The American Lion: the largest lion on earth
The Giant Short-Faced Bear or the Bulldog Bear: the largest bear ever to live
Smilodon populator: Sabertooth cats, I'd bet would be relegated to South America at this point due to competition in North America
The Dire Wolf: similar to the Grey Wolf, but larger, stockier, and more hyena-like in its niche
Equus: three to five species of horse
Camelops, or the Western Camel: A giant camel with a longer neck
Glyptodon: a giant armadillo, or more accurately a walking tank
The Columbian Mammoth: not to be confused with the Wooly Mammoth, this baby is much bigger and hairless. Can you say ivory trade.
The Wooly Mammoth, probably clinging on in the northern Taiga and Tundras
The Giant Ground Sloths: depending on the species can be mild tempered to semi-carnivorous.
The Scimitar Cat:
The Shrub-Ox: related to the Musk-Ox
Long-Horned Bison, as well as three other species:
Teratorns: giant fucking vultures
The Florida Cave Bear: (actually didn't know this one existed until just now)
Giant Polar Bears: probably would be clinging on to life in the current warming we are having
American Cheetah: probably not a true cheetah, but very distantly related. Could probably run as fast as 60 mph, the biological reason for the great speed and agility of the Pronghorn
The American Mastodon: another candidate for abuse in the ivory trade
3 species of Giant Peccaries: who said there weren't any pigs?
Toxodon: a hippo-like animal in South America
Macrauchenia: some weird shit in South America
Cuvieronius: a South American elephant
Now ALL OF THIS plus our current cast of bestial characters, including Polar Bears, Grizzly Bears, Black Bears, Grey Wolves, Deer, Moose, Elk, Caribou, Pronghorns, Coyotes, Jaguars (as far north as Utah before Americans hunted them back to Mexico), Cougars, Llamas, Guanacos, Alpaca, Peccaries, American Bison, Musk-Oxen, Anacondas, Alligators, Crocodiles, Caymans, Giant Otters, Condors, and Bald Eagles.
For Reference.