Hitler wants to invade the Soviet Union really badly. Its the reason for the whole Nazi program.
In our TL, invading the Soviet Union might actually have been the best option available in 1941. There really were not many good other options. Germany really didn't have the weapons to defeat Britain in an air or sea campaign. And in our TL Germany did pretty well in that Soviet invasion, and Soviet survival was a close run thing.
So lets say in this alternate time line Hitler somehow figures out the Soviet Union is stronger than he actually thought OTL (something like: Germany knows about the T34, or figures out the Soviet capability to generate massive reserves, or worries more about their ability to supply such forces over such distances).
So in this TL Germany would almost certainly try to spend 1941 fixing these deficiencies in her armed forces vs. the Soviet Union and plans on attacking in 1942, and in the mean time cleans up further Italy's mediterranean situation. Malta and Tobruk would both fall to the Axis in 1941, however there is much debate on these forums if the Axis could actually take Egypt due to supply issues.
In any case 1942 would roll around, and the USA is now in the war!, the Soviet Union is even stronger and harder to attack, the British Bomber offensive is getting annoying, Britain is still in Egypt. Perhaps Hitler then decides he just isn't strong enough to take that Soviet Invasion on until Britain and the USA are defeated.
The USA/Britain would be able to drive the Axis out of Africa in 1943 but invading Europe is far more risky with the undimished German army around. Stalin, cautious man that he is, won't invade until the Allies are on the ground in Europe in strength.
Allies resort to a bombing only strategy which eventually become effective due to the Allies technical and production superiority. Hitler dies of his ailments in early 1946 and the Nazi state falls apart due to infighting and a massive June 1946 Allied invasion of France wins easily.
(I am assuming the Allies might be more cautious about using the Atomic bomb if the Germans were just across the channel and could retaliate with nerve gas loaded into V2s or something)