The Safavid dynasty briefly retook Baghdad from the Ottomans in 1624 and held it for 14 years, during which Constantinople tried and failed to recapture the city several times before Murad IV finally succeeded in 1638. The Ottoman Empire's control of Mesopotamia, which lasted until its dissolution after WWI, was then confirmed by the Treaty of Zuhab.

Assuming things so sideways for Murad (whose brother and successor, Ibrahim, was insane), could the Safavids hold Baghdad indefinitely, or would the Ottomans come back again and again until they finally reach the Persian Gulf?

 
There is not that much time for the Ottomans to come back. After this war, I think Crete is the only place they ever managed to conquer and from the 1700s it's a slow slide downward. Provided they manage to get an Austrian or Russian alliance, I'd reckon that they definitely could end up holding onto Mesopotamia in the long term. Even without such an alliance they just might.
 
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