1568

Philip and Carlos did not like one another, but suppose that despite that whole ordeal, Philip's health begins to deteriorate for unknown reasons, then completely fails him when Elisabeth dies during miscarriage. This leaves Isabel Clara Eugenia and Catalina Micaela as his surviving children...

What if, the Moriscos Revolt in 1569-1571, was more successful, becoming more large scale, they gain larger support from the Ottomans, and they capture Granada in 1568. The Spanish armies give up because of guerilla warfare, and the conflict draws out, and Kingdom of Granada becomes independent...