The war of Ottomans, Navarre, England, Scotland and France versus Castile, Burgundy, Brittany and Aragon and the new colonies
Isabella of Castile dies in 1506 because she was assassinated by the sympathizers of the Valois Dynasty and La Beltraneja because of the Castillan inheritance of Valois, Joanna la Betraneja married Charles VIII and was a mistress of Louis, the Spider King, Charles VIII and Dauphin Henry declared a war on Castille and Charles VIII declared himself the King of Castille and France and he allied with the Ottomans, Castile and Burgundy treated it as a threat, and they are surrounded by the Ottomans and the French and the war became very bloody and a treaty was concluded granting anything north of Ebro to France, Anne of Brittany and John of Castille only had a daughter named Claudia born June 6 1493 and Claudia married Charles I of Great Britain, the grandson of Elisabeth of York, James IV, La Betraneja and Louis the Universal Spider in 1515 with Charles being a 16 year old and Claudia being a 23 year old, the marriage produced many children Elisabeth, Charles, Eleanor and Anna their children became very marriageable but because James and Claudia had only one son a war of succession started again and the children of Claudia and Charles were disinherited from Castile and Valencia after the death of John I of Spain because Charles I of England and Scotland gave the Spanish inheritance in 1560 to Portugal instead of keeping it to his own line at the death of John I of Spain.
At the reign of John I Spain many colonies were discovered and that included Mexico, Joaninia(OTL Louisiana), Visayas and Taiwan(Hermosa) and because of that the Santiago-Acapulco trade started which enriched spain giving them the richness of the new colonies.
Note:
*In this timeline Mary of Burgundy married Francis II of Brittany.
*Spain south of Ebro merges with Portugal eventually or Portugal becomes a part of Spain.
*Portugal has no Asian trade at this timeline, they were defeated in Goa in this timeline.
*France and Spain are enemies in this timeline and importantly the Valois survive to the present.
*France colonizes land in the americas earlier.