A Martian stranded on Earth (Tesla Edition)

I just read your TL and it is really amazing! You are creating a very different world tech-wise.

Would it be correct to assume that the Interkom countries emphasis the biotechnology while the West is based on cybernetics?
(what is a gamper?)

I noticed that Asimov was still na Interkom citizen - in his SF Works he still creates the Three Laws of Robotics and the Positronic robots stories? How did Arthur C. Clarke fare in your TL? And Rod Serling?

How detective fiction is considerated ITTL?

How the careers of these scientists worked out?
- Alan Turing
- Konrad Zuse
- Grace Hopper
- Rosalind Franklin

What is the status of the these Technologies?
- antibiotics
- powered exoskeleton
- internet
- space-based solar power
 
I just read your TL and it is really amazing! You are creating a very different world tech-wise.

Thank you.

Would it be correct to assume that the Interkom countries emphasis the biotechnology while the West is based on cybernetics?

A more accurate description would be that the Interkom countries, especially the Sovetunio have a different set of ethics, which allows them to go into some territory the (non-fascist) West won't go.

(what is a gamper?)

A word used ITL to describe human without a fore-brain. In most cases artificially induced by chemicals.

I noticed that Asimov was still an Interkom citizen - in his SF Works he still creates the Three Laws of Robotics and the Positronic robots stories?

He does probably. His most referenced work ITL will be about anti-matter.

How did Arthur C. Clarke fare in your TL?

Well, but nothing specifically planned for him yet.

And Rod Serling?

Same for him.

How detective fiction is considerated ITTL?

The same as in OTL. Maybe a little more boring if you life in the contemporary USS.

Comrade Detective: Have you found DNA?

Comrade CSI Member: Yes.

Comrade Detective: Cross reference it with our genetic data bank containing all citizens and permanent residents profile.


Comrade CSI Member: See you in a few weeks at the court then.


How the careers of these scientists worked out?
- Alan Turing
- Konrad Zuse
- Grace Hopper
- Rosalind Franklin

Nothing concrete planned for them yet. Turning might leave England to settle into the gay friendlier Interkom if he is discovered. Woman's right stay the same in the West so neither Hopper nor Franklin fare worse of better than OTL.

What is the status of the these Technologies?
- antibiotics
See next post.

- powered exoskeleton
Played with in the twenties, seen as unsatisfactory and rediscovered once technology progressed enough.
- internet
Different.
- space-based solar power
Yes, but not the way most people might expect.

The following post on the history of antibiotics is unchanged with the exception of the last comment which was newly added. The notes are also updated.
 
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Adam Smith Hates Your Guts
Adam Smith Hates Your Guts

This post is inspired by Jello_Biafra's “Reds”. It is an alternate history discussion taking place in the world of “A Martin Stranded on Earth”. Occasionally I will use the term OCC (out of character), which means that this is a comment from my real self.

What if Antibiotics instead of Phage Therapy?

Sandman:
Before the early 20th century, treatments for infections were based primarily on medicinal folklore. Mixtures with antimicrobial properties that were used in treatments of infections were described over 2000 years ago. Many ancient cultures, including the ancient Egyptians and ancient Greeks, used specially selected mold and plant materials and extracts to treat infections. More recent observations made in the laboratory of antibiosis between micro-organisms led to the discovery of natural antibacterials produced by microorganisms. Louis Pasteur observed, "if we could intervene in the antagonism observed between some bacteria, it would offer perhaps the greatest hopes for therapeutics".

The term antibiosis, meaning "against life," was introduced by the French bacteriologist Vuillemin as a descriptive name of the phenomenon exhibited by these early antibacterial drugs. Antibiosis was first described in 1877 in bacteria when Louis Pasteur and Robert Koch observed that an airborne bacillus could inhibit the growth of Bacillus anthracis. John Tyndall first described antagonistic activities by fungi against bacteria in England in 1875. Synthetic antibiotic chemotherapy as a science and development of antibacterials began in Germany with Paul Ehrlich in the late 1880s.
Ehrlich noted that certain dyes would color human, animal, or bacterial cells, while others did not. He then proposed the idea that it might be possible to create chemicals that would act as a selective drug that would bind to and kill bacteria without harming the human host. After screening hundreds of dyes against various organisms, he discovered a medicinally useful drug, the synthetic antibacterial Salvarsan.

However there were some problems with Salvarsan. It was distributed as a yellow, crystalline, hygroscopic powder that was highly unstable in air. This significantly complicated administration, as the drug had to be dissolved in several hundred milliliters of distilled, sterile water with minimal exposure to air to produce a solution suitable for injection. Leading to Ehrlich's observation that "the step from the laboratory to the patient's bedside ... is extraordinarily arduous and fraught with danger."

The next big find was that of sulfa drugs, specifically by the German Bayer Cooperative in 1936. A research program designed to find dyes that might act as antibacterial drugs in the body. After years of fruitless trial-and-error work on hundreds of dyes, a team led by physician/researcher Gerhard Domagk found sulfonamide. It had a strong protective action against Gram-positive cocci but it had no affect on Gram-negative bacteria. It was also discovered that Sulfa allergies are common in the population, hence medications containing sulfonamides had to be prescribed very carefully. But the worst problem from a business perspective was that sulfonamide or sulfa had first been synthesized in 1906 and was widely used in the dye-making industry; its patent had since expired and the drug was available to anyone.
The world came to the conclusion that the future of medicine was indeed in bacteriophage and a huge phage research and production network was build all over the globe.
It was not until 1953 when Howard Florey discovered antibiotic substance penicillin from the mold Penicillium notatum that antibiotics became really useful. Penicilin is a much more powerful and veristalie than sulfa or any other chemical antibacterial.

Now there is an interesting but not well known fact. Clodomiro Picado Twight a Nicaraguan-born scientist, citizen of Costa Rica, who was recognized for his research and discoveries. He was pioneer in the researching snakes and serpent venoms; his internationally recognized achievement was the development of various anti-venom serums. He also found discovered the usefulness of penicillin, which he used to treat patients. Sadly he died when his laboratory burned down after an accident.
So what if the accident never happens and we get penicillin in the twenties? Will it be seen as important as phage therapy? Is it possible that we reverse the history of medicine and antibiotics are all the rage and phage therapy is only used in few special cases, if at all?

Unbuntu:
I'm not sure, but maybe if you kill off d'Hergelle?

RuleBretonia:
Unlikely, even if you kill d'Hergelle there is still Frederick Twort. Without d'Hergelle he might get the publicity he never got OTL And even if not there are lots of other researcher. You can't simply butterfly something as useful as phage therapy away.

Shetlandpony:
There is a good reason that the discovery of Penicillin was seen as just mildly interesting. Phage therapy is just much superior in basically any conceivable way. Here is a short list of advantages:

1. Bacteria can develop resistance to phage but phages co-evolve with their targets. Bacteria become resistant? Some virus will have the right mutation to crack them anyway. Antibiotics on the other hand are just fixed chemical substances. They don't evolve on their own. Once they get resistant your antibiotics are useless.

2. Bacteriophage are very specific, they only target one or a few strains of bacteria. Antibiotics have a more wide-ranging effect, killing both harmful bacteria and useful bacteria such as those facilitating food digestion. Basically the difference between carpet bombing or using a sniper.

3. Phages can travel to a required site including the brain by crossing the blood brain barrier to combat infections such as meningitis, something most antibiotics can't.

4. Phages are also non-toxic while many antibiotics are.

5. Antibiotics can be patented, bacteriophage which are "living" organisms can't.

Sandman:
Thank you for your responses. I guess my idea was ASM (OCC: Alien Space Mole) then.

Mistress_Rand:
Not necessarily ASM in my opinion. Just very difficult and unlikely. But I'll try anyway. Here is my mini timeline:

Adam Smith hates your guts
by Mistress_Rand

The POD is that Fanya Kaplan is not toppled and successfully shoots Bogdanov on 30 August 1918. There is a leadership crisis, and the Sovetanoj do worse in the Class War. Feeling threatened after their leader's violent death, even more so than OTL, the new leadership reinstates the death penalty. The Cheka (old name for the Stasek) runs amok and the general atmosphere becomes grimmer and grimmer. The German revolution doesn't happen and the economic miracle of the NEP (New Economic Policy) turns into an economic crisis instead.
We get a bloody power struggles and purges of "bourgeois" and "counter-revolutionary" elements in party. In the end the Sovetunio is ruled by a Leninist Troika of Zinoviev, Kruspkaya and Molotov.

Then an obscure figure from our own timeline enters the scene. Trofim Lysenko, born to a peasant family in 1927, at 29 years of age, works at an agricultural experiment station in Azerbaijan.
As in OTL he embarks on the research that leads to his 1928 paper on vernalization, which draws wide attention due to its practical consequences for soveta agriculture. Severe cold and lack of winter snow destroyed many early winter-wheat seedlings. By treating wheat seeds with moisture as well as cold, Lysenko induces them to bear a crop when planted in spring.
Lysenko still makes his false claims that a vernalized state can be inherited - i.e., that the offspring of a vernalized plant will behave as if they themselves had also been vernalized and will not require vernalization in order to flower quickly. Lysenko becomes enormously successful in this ATL Sovetunio because of his peasant background and his enthusiastic advocacy of the Sovetunio and Leninism.

During a period which sees a series of man-made agricultural disasters, Lysenko is extremely fast in responding to problems, although not with real solutions. Whenever the Party announces plans to plant a new crop or cultivate a new area, Lysenko has immediate practical suggestions on how to proceed.So quickly does he develop his prescriptions - from the cold treatment of grain, to the plucking of leaves from cotton plants, to the cluster planting of trees, to unusual fertilizer mixes - that academic biologists do not have the time to demonstrate that one technique is valueless or harmful before a new one is adopted.
The Party-controlled newspapers applauds Lysenko's "practical" efforts and question the motives of his critics. Lysenko's "revolution in agriculture" has a powerful propaganda advantage over the academics, who urge the patience and observation required for science. Lysenko takes his revenge on the scientific establishment once the becomes a People's Commissar. He throws his Mendelian opponents in French style concentration and working camps and destroys the genetic scientific community of the Sovetunio for years to come. The fact that the Mendelian genetics advocate Serebrovsky, can't use his personal connections to Bogdanov to force an early decisive decision in their favor might make this scenario much more likely.

At the same time in South America Picado Twight publishes his manuscripts, in which he explains his experiences with the inhibiting action of fungi of the "Penicillin sp" genre in the growth of staphylococci and streptococci (bacteria that cause a series of infections) between 1915 and 1927. Not merely satisfied with publishing his results Picado becomes more pro-active. He contacts the US company Pfizer.

clorito2.jpg

Picado Twight

The Great War causes a shortage of calcium citrate that Pfizer imports from Italy for the manufacture of citric acid. The company begins a search for an alternative supply and Pfizer chemists learn of a fungus that ferments sugar to citric acid and were able to commercialize production of citric acid from this source in 1919. As a result Pfizer develops an expertise in fermentation technology. (This is OTL)
With their know-how Picado's penicillin can be mass produced and revolutionizes medicine. Meanwhile D'Herelle accepts a request by the British government in 1927 to work in India since his friend Eliava who wanted him to participate in his new research laboratory met a tragic end. Eliava falls in love with a woman, with whom the head of the Georgian secret police, Lavrenty Beria also fell in love. This seales his fate. Eliava is executed and denounced as an enemy of the people during one of the Troika's purges (OCC: That is what really happened to Eliava.)

European and US pharmaceutical companies take up the production of their own phage medicine, and promise impossible effects. Without proper oversight and competition by D'Hergelle. All of the companies suffer from production problems as results from commercial phage medicine are erratic. This is happens due to the attempt to mass-produce something that is barely understood, leading to damaged phages in the product, or to insufficient amounts thereof.
There are also wrong diagnoses leading to the use of the wrong type of phages, which are specific in their choice of their "victims". Furthermore, many studies on the healing effects of phages are badly conducted. All this leads to important parts of the scientific community turning against d'Herelle, who, known for his temper, made not a few enemies.

Phage therapy encounters many obstacles that make it less useful than penicillin. The high bacterial strain specificity of phage therapy makes it necessary for clinics to make different cocktails for treatment of the same infection or disease because the bacterial components of such diseases may differ from region to region or even person to person. In addition, due to the specificity of individual phages, for a high chance of success, a mixture of phages is often applied. This means that “banks” containing many different phages must be kept and regularly updated with new phages.

Further, bacteria can evolve different receptors either before or during treatment; this can prevent the phages from completely eradicating the bacteria. The need for banks of phages makes regulatory testing for safety harder and more expensive. Such a process makes it difficult for large-scale production of phage therapy.
Additionally, patent issues (specifically on living organisms) complicate distribution for pharmaceutical companies wishing to have exclusive rights over their "invention", so no for-profit corporation invests capital in the widespread application of this technology especially not if they have penicillin and other similar antibiotics as an alternative. Funding for phage therapy research and clinical trials is generally insufficient and difficult to obtain, since it is a lengthy and complex process to patent bacteriophage products if it is possible at all.
Scientists comment that “the biggest hurdle is regulatory”, whereas an official view is that individual phages would need proof individually because it would be too complicated to do as a combination, with many variables.

Due to the specificity of phages, phage therapy would be most effective with a cocktail injection, which is generally rejected by the U.S. Food and Drug Administration (FDA). For phage therapy to be successful the FDA must change its regulatory stance on combination drug cocktails, which is most unlikely due to big pharmaceutic company lobbying against it. Public awareness and education about phage therapy is very limited.

The negative public perception of viruses plays a role in the reluctance to embrace phage therapy as well. In the end phage therapy remains a mostly forgotten niche in a world obsessed with antibiotics. Research is conducted by big Pharma Companies that control the nations of the word with their big budgets and lobbying. They prevent any regulation that would help the popularization of phage therapy.
The Sovetunio collapses under the weight of corruption and the ethnic tensions stirred up by radical Russification. Thus the last potential hope for a state sponsored phage therapy network dies. Capitalism rules supreme and the people in developing nations die from preventable disease. Richer people suffer from diarrhea caused by the antibiotics that figuratively carpet bomb away all bacteria, even the useful ones in your intestines. In conclusion Adam Smith really hates your guts ;-).

(….)


Shetlandpony:
I can only join the chorus, please turn this into a full length timeline. Some additional suggestions on things that won't happen at all or will at least be significantly delayed.

a. Stomatology (1) would drastically change. What many people not realize is that the “mouth vaccine” they get are actually bacteriophage that kill bacteria responsible for dental caries but also the production of malodorous compounds and fatty acids (bad breath) and some other stuff.

b. Oncolytic virus may be an example of a more indirect effect. As their name indicates the destroy (lytic) cancer cells (Onco). I am not sure how much for example Blome's work on them was influenced by bacteriophage research, but it probably helped a lot.

c. Bacteriogpahges also played a role in the invention of genetic Surgery (3), the discovery of DNA and in many more developments. If you want I can PM you a list with a few more links.

Notes (OCC):

(1) Stomatology is the branch of medicine and dentistry relating to the mouth and mouth disease. This name for this medical discipline was fairly popular in Eastern Europe of OTL and is more so ITL, since working with bacteriophage goes beyond just “tooth plucking”.

(2) genetic Surgery/ Gene Therapy in OTL

(3) Kurt Blome, one of many scientist working on oncolytic virii therapy. He just happened to be the most successful and well known one.
 
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The Mímisbrunnr
The Mímisbrunnr

It sates itself on the life-blood of fated men,
paints red the powers' homeswith crimson gore.
Black become the sun's beamsin the summers that follow, weathers all treacherous.
Do you still seek to know? And what?”

The Poetic Edda poem Völuspá

Heavy Water

Pure heavy water, 2H2O, is the oxide of the heavy stable isotope of hydrogen, hydrogen-2 denoted by the symbols 2H. It is physically and chemically almost identical to ordinary light water, H2O, except in that its density is 10% higher, hence its name.

Most of the hydrogen-2 (heavy hydrogen) was formed about 10 minutes after the Big Bang, along with other very light isotopes presently found in the universe. More recently, 2.5 billion years ago, most of the deuterium atoms on the earth were incorporated into water molecules. As a small isotopic fraction of natural hydrogen (0.015%), deuterium existed then, as now, mostly in the form of H2HO molecules. And this is the way things remained until heavy water was discovered in 1913.

Arthur Lamb and Richard Lee were trying to improve measurements of the density of water at the New York University. This was seen as an important quantity to know accurately because of its importance as a scientific standard. They were attempting an accuracy of 200 ppb, but were not able to get agreement between samples taken from diverse geographical locations to better than 800 ppb.
They speculated that the novel concept of isotopes, as developed by Frederick Soddy and Kasimir Fajans, that had been recently been announced, might be behind their problem. He showed that a radioactive element may have more than one atomic mass though the chemical properties are identical. He named this concept isotope meaning „same place“.

The reason for the discrepancies measured by Lamb and Lee was indeed that the abundance of hydrogen-2 varies due to rates of evaporation and condensation. The next important person involved in the discovery of hydrogen-2 was Kristian Birkeland.

1.1.2.Vemork-kraftstasjon.jpg

Vemork hydroelectric power plant and heavy water production facility

Coil Guns, Fertilizer and Hydrogen-2

Birkeland organized several expeditions to Norway's high-latitude regions where he established a network of observatories under the auroral regions to collect magnetic field data. The results of the Norwegian Polar Expedition conducted from 1899 to 1900 contained the first determination of the global pattern of electric currents in the polar region from ground magnetic field measurements.

The scale of his research enterprises was such that funding became an overwhelming obstacle. Recognizing that technological invention could bring wealth, he developed an electromagnetic cannon and, with some investors, formed a firearms company. The coil-gun worked, except the high muzzle velocities he predicted (600 m/s) were not produced. The most he could get from his largest machine was 100 m/s, corresponding to a disappointing projectile range of only 1 km. So he renamed the device an aerial torpedo and arranged a demonstration with the express aim of selling the company. At the demonstration, one of the coils shorted and produced a sensational inductive arc complete with noise, flame, and smoke. This was the first failure of any of the launchers that Birkeland had built. It could easily have been repaired and another demonstration organized.

However, fate intervened in the form of an engineer named Sam Eyde. At a dinner party only one week later, Eyde told Birkeland that there was an industrial need for the biggest flash of lightning that can be brought down to Earth in order to make artificial fertilizer. Birkeland's reply was, "I have it!"
There were no more attempts to sell the firearms company, and he worked with Eyde only long enough to build a plasma arc device for the nitrogen fixation process. The pair worked to develop the prototype furnace into a design that was economically viable for large-scale manufacture. The resulting company, Norsk Hydro, hugely enriched Norway, and Birkeland then enjoyed adequate funding for research, his only real interest.

The Birkeland–Eyde process is relatively inefficient in terms of energy consumption. Therefore, in the 1910s and 1920s, it was gradually replaced in Norway by a combination of the Haber process and the Ostwald process.Birkeland wasn't particularly upset with this development, he was furthermore elated when he realized that the new technology might allowed him to test Lee and Lamps very cautiously formulated hypothesis. Since large amounts of water were already being electrolyzed as part of the Haber-Bosch process, with a few modification a successful experiment could be conducted to generate purer heavy water.

The idea was simple. It relied on the fact that the heavier water isotopes (it wasn't clear yet if oxygen or hydrogen were responsible for the weight difference) would be less likely to be removed at the cathode than normal atoms. The industrial procedure is to electrolyze a large tank of ordinary water till it's nearly all broken down, collect the enriched water that's left and store it in a second tank, This procedure is then repeated until the second tank is full of enriched water - then it was started all over again, electrolyzing the enriched mixture, and so on. All of this could be basically done with the existing infrastructure. Just a few tweaks were necessary. After evaluating he pros and cons of Birkeland's idea Samuel Eyde supported him and freed up the resources necessary.

In 1916 in the middle of the Great war a sufficiently high percentage of 2H2O was produced not only to measure the weight difference to normal water but also to identify hydrogen-2 with spectroscopic analysis. The existence of heavy water and hydrogen-2 made quiet some waves, even thou these were not the best times for basic research .

Notes and Sources:

Waltham, Chris (1998): An Early History of Heavy Water.

Gilbert N. Lewis; Ronald T. MacDonald (1933): Concentration of H2 Isotope.
 
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The history of Eugenics in the USS
The history of Eugenics in the USS


The formation of Socialist Eugenics Science

Although the first Russian translation of Francis Galton's “Hereditary Genius“ appeared in 1874 the subsequent quarter century saw little interest in eugenic ideas in Russia, and no other works by the founding father of eugenics were published. Francis Galton was a cousin of Charles Darwin who's book "The Origin of Species" changed Galtons life forever. He was fascinated with the work, especially the first chapter on "Variation under Domestication" concerning the breeding of domestic animals. Galton devoted much of the rest of his life to exploring variation in human populations and its implications, at which Darwin had only hinted. In doing so, he established a research program which embraced multiple aspects of human variation, from mental characteristics to height; from facial images to fingerprint patterns. This required inventing novel methods to measure traits, the large-scale collection of data and the discovery of new statistical techniques for describing and understanding them. These ideas and techniques were described in his aforementioned "Hereditary Genius" which he published in 1869. Galton also invented the term eugenics in 1883 and set down many of his observations and conclusions in the book, "Inquiries into Human Faculty and Its Development".

dkZtM.jpg

Francis Galton

There were several reasons that the concept of eugenics didn't get much attention in the Russian Empire. Russia lacked the socioeconomic conditions, that were fueling the eugenics movement elsewhere. The Empire was huge, sparsely populated, predominately agrarian, autocratic, poly-confessional and multi ethnic. Overpopulation or being overwhelmed by mass immigration weren't concerns, neither was the fear of a degenerated, urban worker and paupers class out-breeding the precious middle and upper class.
Around 1900 the advent of Industrialization along with the rapid growth of medical, scientific, pedagogical and legal professions began to change the situation. During the first decades of the twentieth century, eugenic ideas started to filter into Russia. Russian eugenicists were well informed of the varied approaches to the issues of “human betterment” by selective breeding.
While Russian proponents of eugenics were inspired by Western contemporaries, the majority of them criticized the “race” and “class” components of eugenic ideas and policies, which were most prevalent in the German and Anglo-Saxon discourse. Their work empathized more the education and general nurture side of the debate, as it was the case in France. They rejected “negative measure” like sterilization and segregation and instead advocated the improvement of social conditions, education and the use of eugenics as a form of voluntary prophylactic medicine.

The Russian response to the First International Eugenics Congress held in 1912 in London displayed these features prominently. Although Russia didn't sent official representatives to the congress at least two Russian men attended the sessions anyway. These men were the eminent philosopher and theoretician of anarchism and author of “Mutual Aid: A Factor of Evolution (1902)[FONT=Times New Roman, serif]" [/FONT]Petr Kropotkin and the popular journalist Issak Shklovsky. Kropotkin delivered a passionate speech against the congress class bias “Who are the unfit?” he exclaimed rhetorically “the workers or the idler? The women of the people who suck their children themselves or the ladies who are unfit for maternity because they can't perform their duties of a mother? Those who produce degenerates in slums, or those who produce degenerates in palaces?” Kropotkin vehemently opposed the proposal to sterilize the “unfit” insisting that such social measures as the abolition of slums “will improve the germplasm of the next generation more than any amount of sterilization” .

Shklovsky echoed Kropotkin's criticism. The title of his correspondence from the congress “Beastly Philosophy” speaks for itself. While Kropotkin attacked the “class” components of eugenics ideas, Shklovsky focused his critic on “race”. His criticism can be best summarized in this comment of his: “All those purportedly scientific data upon which the doctrine of higher and lower races are based can not withstand criticism for the very simple reason that anthropology knows no pure races”. The most influential, early enthusiast of eugenics in the Russian Empire was the anthropologist Ludwik Kryzwicki who wrote extensively on eugenics and was the one who coined the term antropotekhnika (antoropotechnique) a term derived form the Russian word for animal breeding zootekhnika (zootechnique).

Kryzwicki was however much more enlightened about the whole concept, than other followers of Galton. While he wrote “eugenics offers us the opportunity to become more than the simple observers of humanity” in the same sentence he also cautioned not to use “hasty application of negative eugenic ” since they might “at the present time turn into the instruments of narrow class interests”.
Many Russian physicians were sympathetic to eugenics. For doctors eugenics offered a new research methodology (medical family histories, twin studies, and statistical analysis) and a new interpretative framework, replacing the old vague idea of “inborn constitution” with the new principle of heredity. During this period several doctoral dissertations on “heredity and disease” were defended in Russia. A programmatic statement opening the first issue of a new journal “Hygiene and Sanitary Science” in 1910 argued that “generative hygiene [eugenics]” ought to constitute an important part of Russian public health agenda. The last but in the end most important group interested in eugenics were Russian biologist, first and foremost Nikolai Koltsov and Yuri Filipchenko two of the founders of Russian Genetic Research.

In the years prior to the Bolshevik Revolution of November 1917 eugenics failed to spark an organized movement or find an institutional setting. The situation changed dramatically after the revolution. Despite the bloody class war, famines epidemics and economic deprivation eugenics societies, research institutions and specialized periodicals thrived. Eugenics entered teaching curricula and found grass root following nationwide. The Bolshevik revolution liquidated the private endowments that supported Koltsov's Institute of Experimental Biology, which he had established in 1916. This forced Koltsov to search for new patrons among the newly created Bolshevik state agencies. Two circumstances helped him in that quest.
First Nikolai Koltsov had a long history of being politically active and supportive of the socialist cause. In the the days of the Revolution of 1905 Koltsov joined the newly formed socialist “Circle of Eleven Hot-Heads” lead by the astronomer Paul Karlovic Sternberg. Sternberg worked at the Observatory of the Moscow University where the circle held their first meeting but for security reasons they shifted their base of operation from the observatory to Koltsov's office. Here the revolutionary collective organized protests, petitions and printed on mimeographed underground propaganda leaflets.

9mPUB.png

Genetic Counseling

Koltsov's state of mind during this period is best characterized by his short book “In Memoriam. Victims from among the students of Moscow in October and December days.”
Income from the publications supplied the committee to assist prisoners and pardoned. It was sold for a price of 50 kopeks in 1906. The book not only gave out the names of the victims but in detail described the circumstances of their death, and included various excerpts from newspapers as well as comments from Koltsov himself. One example for a newspaper article was Czars Nikolai's speech in which he thanked the student's killer for their heroic deeds, as he said "The sedition in Moscow has been broken."
The book was released at the same day, that the new state Duma held its first meeting. The book was almost immediately confiscated, but more than half of the circulation had already managed to disperse. Shortly after the suppression of the revolution Koltsov had scheduled his Doctor Thesis defense, but refused to defend his work “behind the doors”. This comment was not as one might think a figure of speech but a sad reality. The University was at the time patrolled by soldiers to ensure "law and order" and the professors were literally working behind closed doors, since no public lectures were allowed yet. In 1909 Nikolai Konstantinovich Koltsov was finally banned from teaching for his political views and quit from the university in 1911 joining other famous teachers who did the same.

The second advantage he had was his good relationship with The People's Commissar for Public Health Protection Nikolai Semashko, a Bolshevik physician who was himself an active proponent of social hygiene and the leading force of its institutionalization. Eugenics found its first institutional home in the State Museum of Social Hygiene, created by the Commissariat for Health Protection in January 1919.
Under Koltsov's imitative the "USS Eugenics Society" was founded in November 1920. One of the other founding members the anthropologist Viktor Valerianovich Bunak became the director of the eugenics department at the Institute for Experimental Biology which Koltsov had created already in 1917.
As the head of the whole Ineksbio Koltsov was responsible for the general scientific direction of the institute, but he also found the time to be the editor in chief of the Eugenics Society's publication the “USS Eugenic Journal”. Parallel to Koltsov, Yuri Filipchenko had organized the USS first genetic department at the Petrograd University and a genetic laboratory within the University's Institute of Natural Science. He also advocated the establishment of a Department of Eugenics inside the People's Commissariat of Health Protection to study the “questions of heredity specifically in application to humans” and “to implement the results in form of a general socialist eugenics policy”. Shortly after the first issue of the “USS Eugenic Journal” was published he joined Koltsov on the editorial board.

Having built the institutional bases the champions of Russian eugenics began to revive their international contacts, reviewing current Western works on eugenics and arranging for their Russian/Interlingvo translation. However soveta eugenics did not simply, slavishly follow the path of its Western counterparts. It was profoundly shaped by the local traditions, as well as the institutional and ideological landscape.
In his inauguration address as the new and first president of the “USS Eugenic Society” Koltsov identified three key components of eugenics. The first was “pure science” or “anthropogenetics” gathering knowledge of human heredity.
The second “applied science” which echoing his pre-revolutionary predecessors termed “anthropotechnique”. The task of anthropotechnique was to find appropriate methods of improving the genetic quality of future generations. The third and last was “eugenic religion” a concept inspired by the new and highly active movement of Cosmism. Koltsov sought to integrate the concept of eugenics into the new secular church's doctrine in order to espouse an “ideal” that would “give meaning to (human) life and motivate people to sacrifices and self-limitations”. The “USS Eugenic Journal's” second issue carried an article “On the tasks and paths of anthropogenetics” written by Koltsov's student and future head of the “Department of Anthropotechinque” Aleksander Serebrovsky which outlined the research methodology and agendas of the new science.

Between 1920 and 1925 the USS Eugenics Society published and lectured to professional and lay audiences, organized exhibits and public discussions, and advocated the inclusion of courses on general biology in the syllable of secondary schools and universities. This propaganda bore plentiful fruits, by the mid-decade, the USS Eugenics Society membership included psychiatrists and anthropologist but also gynecologist, pedagogues, public health and education officials, jurist neurologists and criminologist. During the early 1920 local chapter of the USS Eugenics Society appeared all over the Union, as well as independent eugenics groups which appeared in many provincial centers. Furthermore eugenics found a grassroots following; in 1926 Koltsov received a request for advice and support from the “Eugenic Society of Perfectionists” a small commune organized by several enthusiasts in southern Russia to put ideas of “eugenic marriage” into practice.

Eugenic ideas also became the subject of popular plays and fiction which generated lively debates in literary and theatrical circles and among the general public. Soveta futurist Sergei Tretyakov's popular pro-eugenics discussion play “I want a Child (1927)” is certainly the most famous example. The play's main character is Milda, a cultural education worker who decides that she wants to have a baby, without a father or a family, bred from best proletarian stock of her choice.
The child is to be raised by the communal child-rearing organizations that Milda herself is helping to establish as part of the Bolshevik’s effort to construct the ideal socialist state. Doing her best to ignore the meddling and scorn of the unruly co-tenants in her crowded Moscow apartment block, Milda sets out to complete her mission. Eventually she fulfills her dream after a laborious, comic, melodramatic, and tragic journey.

The geneticists Koltsov and Filipchenko initiated the institutionalization of soveta eugenics but practicing physicians interested in hereditary disease also became engaged. In 1922 Kiev University professor Alexei Krontovsky established a “bureau for studies in human heredity” to study the “human pathological heredity and constitution”. Many more similar efforts followed. The particularities of the newly created soveta public health system, with its focus on prevention, the social contexts of health and the protection of maternity and infancy expressed in organizations like Propainfan provided a fertile ground for these new ideas.
According to the founder of the “Circle of Materialist-Physicians” Solomon Levit the “reconstruction of the soveta medicine on a prophylactic basis” would be the theoretically unthinkable without the “reconvention of the inheritance of acquired characteristics”. Nevertheless there still was a notable amount of criticism which supporters of eugenics spent considerable effort answering. Commissar Semashko published an article tellingly entitled “Eugenics, Theirs and Ours” which called for clear distinction between “Western, Bourgeois” and “Soveta Proletarian” eugenics. Koltsov and Filipchenko together with Chetverikov waged a coordinated campaign against Lamarckism in popular and professional periodicals.

Serebrovsky went even further, he joined the Socialist Academy to oppose the critics, which were mostly socialist philosopher rather than actual scientist, form within their main base, claiming that modern genetics represented the “truly Marxist and Tectological” view while Lamarckism was “anti-Marxist” and reactionary. Moreover to assuage the accusation of elitism Serebrovsky introduced the notion of a “gene fund” describing it as the “nation's genetic capital”. Since a nation's population possessed “a gigantic gene fund” which contained countless genes of creativity, talent and genius, a true socialist would seek the utilization and redistribution of this genetic wealth. This Serebrovsky argued was “the primary task of soveta eugenics”. Following this reasoning Serebrovsky identified a “truly socialist” way of achieving eugenic goals; the “separation of love and reproduction” and the artificial insemination of soveta women with “recommended sperm” from “talented producer”. Of course to implement this vision Serebrovsky noted, the country needed to expand research on anthropogenetics considerably. Most soveta eugenicists came to advocate positive eugenics, “the direct introduction of desirable heritable changes whether by the control of mutation or by encouraging people with the desirable traits to have more children, rather than negative eugenics, namely sterilizing the “unfit”

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Alexander Serebrovsky
.
Interestingly both Bogdanov as well as Lunacharsky were initially Lamarckists, at least to a certain degree. But they were swayed by the overwhelming evidence in favor of Mendelian genetics. It also helped that that Bogdanov accepted Darwin's theory in general and had only held the fairly common idea that acquired characteristics could be somehow additional inherited as well. Lunacharsky however was a Lamarckist because genetics would make people “slaves of the past” while Lamarckism made them “captains of the future”. The idea was that evolution only due to random spontaneous mutation stood counter to any systematic planing effort. A rather dogmatic approach which could have become problematic.

Luckily Serebrovsky had a good personal connection to these most important Bolshevik leaders Bogdanov as well as Lunacharsky. At the end of 1883 Sergei Mitrofanovich Serebrovsky, Alexanders father and a reasonably successful architect had moved with his family to Tver, and four months later settled in Tula. Searching for a suitable place of service, Sergei Mitrofanovich Serebrovsky went in February 1894 to St. Petersburg. There he attended a meeting of Marxists and got acquainted with Vladimir Ilyich Lenin and his wife Nadezhda Krupskaya. The Serebrovskys invited the Social Democrats exiles to visit their home any time and in particular Lunacharsky and Bogdanov made good use of that offer. Sometimes they even held their illegal party meetings there. While the general historical consensus in the USS stresses the (almost inhuman) rationality of the Bolshevik leadership “irrational” factor such as personal connections should not be underestimated. One might go so far as to say that the early and crushing victory of the Mendelian faction in the field of biological science wasn't only the inevitable outcome of the internal rationality of the scientific system, but that the support of the Sovetunio's two most important men played an important role as well. Even if nothing else they definitely influenced the decision of which projects got founding and what would be taught in the USS education system.

Notes and Sources

The connection between Bogdanov, Lunarchasky and Serebrovsky and his father is OTL.

Rosenthal (2002): New Myth, New World: From Nietzsche To Stalinism.

 
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Going back to your previous update, was there a reason for its change, so that now we have the Japanese instead of the Sovetoj as the first to start the long road towards an efficient nuclear fusion reactor? Did Yoshio Nishina's work suddenly reveal itself to you on the Road to Damascus :)D) or is this only the prelude to more posts on scientifical developments in the Fascist countries, up till now quite neglected? After all, if we're going to have an Axis-Interkom war the Fascists had better start living up to the TL subtitle A world where the Avant-garde is triumphant.
 
Going back to your previous update, was there a reason for its change, so that now we have the Japanese instead of the Sovetoj as the first to start the long road towards an efficient nuclear fusion reactor? Did Yoshio Nishina's work suddenly reveal itself to you on the Road to Damascus :)D) or is this only the prelude to more posts on scientifical developments in the Fascist countries, up till now quite neglected? After all, if we're going to have an Axis-Interkom war the Fascists had better start living up to the TL subtitle A world where the Avant-garde is triumphant.

The reason I changed the origins of the fusion reaction are manifold. But the essential reason is that having the USS discover the fansworth fusor wouldn't change much. There is nothing new to learn about the USS this way nor will the technology really become viable or particular useful for them (I only work with things we know in OTL. So far there is no efficient fusion technology, not even on paper.)

Having the Japanese invent the technology on the other hand makes things interesting again. We can as you suggested in your post yourself explore the Japanese culture (one of the Axis powers) and at the same time steer them into the right scientific direction. They will be much earlier and more seriously be involved with nuclear technology. Also hhanks to the fusor everybody now has a neat, cheap neutron source to experiment with, so that is a plus as well.

The triumph will have to be earned. That means the Axis and the West stay around for a while to be become and be worthy adversaries.
 
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A Scientific Prohibition:How Moses Parted People from Alcohol
A Scientific Prohibition:How Moses Parted People from Alcohol


"I don't think prohibition is practical. The Germans, you see, prevent it. Look at them. I am sorry to learn that they have just invented a method of making brandy out of Sawdust. Now, what chance will prohibition have when a man can take a rip saw and go out and get drunk with a fence rail?

What is the good of prohibition if a man is able to make brandy smashes out of the shingles of his roof, or if he can get delirium tremens by drinking the legs off his kitchen table."
Mark Twain in the Los Angeles Times, 1908


Twain was somewhat proven right by the failure of the prohibition in America. But he overlooked one obvious question: "What happens if you put the German in Charge of the Prohibition ?"
In order to get an answer we have to look no further than back to the twenties and the the story of the German Volkskommissar for Public Health Julius Moses.
Julius Moses was born in 1868 as the son of Isidor Schneider and his wife Pauline in Poznan. He and his eight siblings, of which only four survived into adulthood grew up in relative poverty. In 1880 Moses moved to his uncle Moritz who didn't have children on his own. Moritz had found some modest prosperity ever since he had settled down in Greifswald.

Here he studied medicine after graduation in 1888 from high school. About his Greifswald time Moses wrote later: "I never encountered any anti-Jewish sentiments in my time there. Never! Greifswald always had a free-minded citizenry. This found expression in the fact that it always send liberal MPs into the Reichstag - often known professors of the university “.
These productive and happy years were crowned by his doctorate with the thesis on Hemophilia in 1892. After having finished his education, he moved to Berlin to open a private practice there.
In 1895 he held his first political speech at the March celebration of the “Deutsch-Freisinnigen Arbeitervereines” (Free German Worker Association) and called for the erection of a monument dedicated to the fallen martyr of 1848 revolution. He married his first wife Gertrud Moritz in 1896 and together they had three children. 1902 began his "Jewish Era". From 1902 to 1911 he was editor of the weekly published Generalanzeigers für die gesamten Interessen des Judentums in Berlin general indicator for the overall interests of Judaism with a print run of 25,000. Later he also became editor at the medical journal Der Kassenartz (the family doctor), the organ of the Association of General Practitioner Associations in Berlin.

On the topic of antisemitism and how to deal with it he he published the anthology “The Solution of the Jewish Question. A survey initiated by Dr. Julius Moses.” in 1907. Examples of people who contributed were Eduard Bernstein, Rainer Maria Rilke and Thomas Mann (1).

After years of searching for the right place in the German political landscape he became increasingly frustrated with the lack of political action of the left wing of the liberal movement. In 1912 he finally joined the ranks of German social democracy. His disappointment with the policy of the Liberals he came to term trough his trademark Jewish humor (3). He wrote a pamphlet entitled "What the Liberals have done for progress in Germany? An open response to an open question.“ Once the interested reader opened Moses's the brochure, he was confronted with a clear answer, blank pages.


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Julius Moses


But the first decade of the twentieth century was not only the time he found home in a new party but also a new love. He and Gertrud parted ways, although they did not yet divorce officially, and sought out new partner. Moses met his future wife Elfriede Nemitz (daughter of Anna Nemitz) trough their shared work for the SPD in 1913. The two later married and had two children together.


During the First World War, Moses joined the USPD, which had split from the SPD, after the controversy over the granting of war credits. Since 1919, Moses belonged to the party line of the USPD. "I say, the conscious alone is the one who decides. Not the program and not the tactics. Things never happened as rapidly as today, we hinder our own work with too many programs and resolutions. Those who don't follow the tides of time will be swept away by them and drown."

Immediately after the end of World War and the Revolution the Socialist Unity government started to develop a new public health program for the young Republic. The input came from the “Verband der Hausarztvereine” (Association of Doctors) as well as selected scientist and socialist party member.
They suggested the creation of a People's Commissariat of Health with the enough power to radically alter society. Their petition said that: „It is recommended to think about the benefits that the improved health of the people has on the overall economic productivity when the Central Committee will approve the final budget.”


Moses was heavily involved in drafting the proposal and was rewarded for his hard work and loyalty to the socialist cause by becoming the first German Volkskommissar for Public Health.
Moses Commissariat tackled a diverse fields of public health concerns such as the raising of public health by improving working and living conditions, the fight against sexually transmitted diseases and sexual education.
But he also cared about promotion science and supported research funding. For him the advancement of science was a "vital part of the march of technological and maybe even more important social progress”.

Moses had a combination of both those field in mind when he asked Louis Lewin to chair a research team that would draft the scientific basis for the future state policy concerning addictive substances first and foremost alcohol. So far there was too much hysteria and not nearly enough substance to base a sound public health program on the use of drugs. Louis Lewin himself was a Jewish-German physician, pharmacologist, toxicologist and author. He was also one of the founder of industrial toxicology and modern drug research.

In 1881 he habilitated in pharmacology (now Pharmacology), toxicology and hygiene and married Clara Wolff, who supported him in his extensive work as an author by proofreading it. In 1893 he was awarded the title of professor, but no real official teaching position was awarded to him. He taught his students and non-medical people in overcrowded private rooms about the effects and side effects of drugs.
In 1887 he traveled trough the USA and Canada together with his wife. He brought with him some pieces of the Peyotl cactus (Mescale buttons) and identified some of it's substances. Among them was mescaline. Later he was one of the first to created a classification system for drugs and psychoactive plants, based on their pharmacological effect.

It was as late as 1919 that he got a real professorship at the Technical University in Berlin-Charlottenburg and only in the aftermath of the revolution did he get to teach in an official capacity. The reasons for this were manifold. Some colleagues were jealous of his success, he was seen as a little eccentric, there was the antisemitism but the first and foremost reason was probably the fight for worker's rights and environmental safety. In countless court cases he appeared as an expert. Together with August Bebel and Rosa Luxembourg, he was a member of the "Committee for Homeless Shelter.” The later did not forget who was there when few stood up for the weakest in society and trough her considerable political weight behind him.

When Lewin was contacted by Moses in 1923 he was already a well respected and highly decorated man. He nevertheless was very interested in helping to shape Germany's drug policy although he regard industrial safety and good work condition in general still as his first priory.
The lesser, personal vices were secondary “luxury” problems (He thought so in OTL as well).

Under Lewin's leadership and three years of hard, diligent work the first Reich's drug report was finished. It was updated over the next years but the core findings stayed. The report dealt with a variety of addictive drugs. By far the oldest and most prevalent was alcohol (2)
When the committee member began their survey they had essentially two models for a possible way to conduct a prohibition, the American and the Soveta model. There was also of course the third option of keeping things as they were.

It didn't take long to realize that the American prohibition policy was not only failing but also showed severe side effects. Prohibition was instituted with ratification of the Eighteenth Amendment to the United States Constitution on January 16, 1919, which prohibited the "...manufacture, sale, or transportation of intoxicating liquors within, the importation thereof into, or the exportation thereof from the United States..."

Congress also passed the "Volstead Act" on October 28, 1919, which created a laughably undermanned and underfunded agency called the Prohibition Bureau, which at its height had no more than 3,000 agents to cover all of the Chicagoland area, but most large cities were uninterested in enforcing the legislation, leaving an understaffed federal service to go after bootleggers. Although alcohol consumption did decline as a whole, there was a rise in alcohol consumption in many cities along with significant increases in organized crime related to its production and distribution.

The situation in the USS was a little different. Prohibition as introduced in the Russian Empire in 1914 permitted the sale of hard liquor only in restaurants. It was introduced at the beginning of World War I. Other warring countries (e.g. the United Kingdom, France, and Germany) imposed certain restrictions on alcoholic beverages, but only Russia completely stopped the retail sale of vodka. Once in office the soveta Popolkomisaro Nikolai Semashko had to see that while this was true on paper the Russian reality looked a lot bleaker.
Instead of trying to enforce the dry laws more rigorously he tried to think outside the box, namely to replace alcohol, especially vodka trough soma. The substitution policy, so far, wasn't a smashing success but at least it seemed to go somewhere. Nevertheless cultural inertia were hard to overcome.


Getting people to stop drinking alcohol for good seemed to be an impossible undertaking. But there are few obstacles that can't be overcome by German engineering prowess paired with Jewish wit.
The solution came in form of “alcohol vaccine, a light-gray crystalline powder.”


While he had the leadership position in the committee, Lewin still kept up with the newest discoveries in the field of chemical safety. A Berlin chemist, M. Grodzki, reported in 1881 that he had synthesized a new compound tetraethylthiuram monosulfide. His report, published in Berichte, caused little attention. This was the heyday of organic synthesis, when chemist, and German chemists in particular, produced one new compound after the other. Grodzki’s seemed to be just one more. However, some twenty years later, disulfiram was introduced in the developing rubber industry to accelerate the vulcanization of rubber. The substance proved effective and was widely used in the vulcanization of both natural rubber and synthetic rubber products.

The initial idea to look investigate this effect came to Lewis a little earlier. Since the early
years of the twentieth century it had been known that cyanamides produce hypersensitivity to alcohol in workers. Based on the Frank-Caro process, atmospheric nitrogen was transformed into calcium cyanamide, which is used as a fertilizer. The anti alcoholic effect was first described by the German physician Franz Kölsch in 1914 and subsequently verified by other studies, but the causal mechanisms remained unknown (4). Lewis had already contemplated about its usefulness for a therapeutic purposes but had been distracted by more pressing matter.

It was in connection with the rubber industry that a possible connection between disulfiram
and the ingestion of alcohol was first noticed by physician’s treating worker in the Swedish rubber boot industry. Lewis established a separt working group that initiated systematic studies in order to develop a disulfiram-based drug, to understand its physiological actions, and to establish its efficiency in clinical trials apart from the rest of the study.

Soon they realized the crucial importance of acetaldehyde. One of their collaborators, a chemist, happened to enter the laboratory and pointed out the strong smell of acetaldehyde. Most of them, being present in the room, had not noticed the smell because they had slowly adapted to it. This observation gave them the key to understand the process. Further experiments proved that when acetaldyhyde was injected intravenously it resulted in the same symptoms as previously experienced. (Later enzymatic experiments proved that the oxidation of acetaldehyde, the first step in the oxidation chain of ethanol, was impeded by disulfiram in concentrations 1 : 107.)

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"It is not too late. The Alcohol Vaccination helps!"
USS Anti-Alcohol Propaganda

One more accidental observation paved the way for the alcohol vaccine. A sample of disulfiram had accidentally been polluted with small amounts of copper. The scientist noticed that that the dark precipitate did not disappear by following the standard procedure of washing with ethanol.

They succeeded in removing the precipitate by recrystallizing with carbon tetrachloride and in this
way also securing a better drug. After the solvent had evaporated, disulfiram was left in a state with a much larger surface and therefore more easily absorbed in the organism. This form of disulfiram is what we commonly call the "alcohol vaccine".


In the end Moses mostly followed the guidelines of the final report. He was however wary of the suggestion of a wider introduction of the vaccine. Moses held a very strict, uncompromising view on the ethics of human experiments.
He found himself fairly often in bitter arguments with the proponents of a more technological progressive stance. Many new and stricter rules constrained the scientific establishment in contrast to the Laissez-faire Sovetunio. There were many reasons for his skepticism of the medical establishment. One of them he explained in his famous article „Hundert Ratten und zwanzig Kinder!“ (One hundred rats and twenty children!) he condemned the practice of using children of worker and immigrants as guinea pigs abusing the still existing gap in education and wealth to get compliant test subjects. A more comprehensive collection of his arguments can be found in his book Der Totentanz von Lübeck 1930. In the end as much as he was beloved, there were many who were more than happy that the "Zementkopf" (concrete head) Moses left office.

Unlike Moses his colleague Semashko saw nothing wrong with immediately implementing the new knowledge and even went so far to start treatment in schools of high risk areas. There is no tolerance to disulfiram: the longer it is taken, the stronger its effects. As disulfiram is absorbed slowly through the digestive tract and eliminated slowly by the body the effects may last for up to two weeks after the initial intake. Disulfiram does not reduce alcohol cravings, and therefore a major problem associated with this drug is extremely poor compliance. Thus the need to make it mandatory mandatory and preferably begin vaccination before a “taste” for alcohol can even be developed. Any concerns about long time health risk were brushed away by Shemashko who was convinced that things could hardly go worse than the prevalent alcoholism right now.


Notes and Sources

(1) Moses, Julius (1907): „Die Lösung der Judenfrage. Eine Rundfrage, veranstaltet von Dr. Julius Moses“.

(2) The report is modeled after the House of Commons Science and Technology Committee's report Drug classification: making a hash of it? from 2006 which came to somewhat similar conclusions.

(3) ITL as well as OTL Moses believed that one could have sharp debates without attacking other people on a personal level. He saw humor and irony as the best instruments to get his positions as well as critic of the other side across to his listeners. He admired the German version of Punch Magazine (Berliner Krakehler 1848-1849) and also started his own illustrated humorous magazine in 1902 the „Schlemihl“ (Yiddish for Jester). While active in the parliament he wrote down the "Ten Commandments of Moses for parliamentary novices and kept a collection of the most "memorable" speeches held in the Reichstag.

Bungert, Mario (2006): Julius Moses - Schrittmacher der sozialdemokratischen Gesundheitspolitik in der Weimarer Republik.
Friedrich-Ebert-Stiftung, Berlin

Kragh, Helge (2008): From Disulfiram to antabuse: The invention of a drug.
University of Aarhus

Kölsch, Franz (1914): Über neuartige Erkrankungen in Kalksticksfoffbetrieben.
München med. Wschr. 35
 
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The Fyodorov Society III
The Fyodorov Society III

The Pioneers of Head Transplantation

“The chemical or physical inventor is always a Prometheus. There is no great invention, from fire to flying, which has not been hailed as an insult to some god. But if every physical and chemical invention is a blasphemy, every biological invention is a perversion. There is hardly one which, on first being brought to the notice of an observer from any nation which has not previously heard of their existence, would not appear to him as indecent and unnatural."
J.B.S. Haldane (1923): "Daedalus, or, Science and the Future.
"

In order for human resurrection to take place there are obviously two major obstacles to overcome. The first is to revive the frozen heads but the second is finding a way of reattaching them to new bodies. This was very simple in the case of insects but much more complicated when tried in mammals or human.

Bakhmetiev himself started testing his idea of potential head transplantation with insects in 1919. After all they had already served him well in his freezing experiments. To his delight they worked exceptionally well. He worked with water boatmen, meal worms, and common butterflies – both in adult and grub form. The transplantation process was not complex (1).
He’d grab two insects, cut off their heads with sharp scissors, and switch them. The fluid that the insects themselves leaked cemented the new heads in place. After a few weeks, the insects were healed up and doing whatever their new heads told them to do. Bakhmetiev found that the heads of female insects on male bodies continued female behavior, and the head of one species of butterfly kept the habits of its own species, even when its body belonged to a different species.

Another interesting discovery happened while studying how certain moth pupae know when to turn into full-grown moths, researchers had a hunch that the pupae depended on getting through a winter first. This meant that the pupae had to be exposed to very cold temperatures, or at least their brains did. The scientists grabbed some moth pupae brains, chilled them down, and stuck them in the abdomens of pupae that had never been chilled. Sure enough, the loose brains started releasing hormones that causes the moths to develop.

Obviously these model organism were much more simple than human, but these experiments nevertheless excited the public and were good propaganda for the new cosmist polices and the Society. Shortly after these and the guinea pig experiments took place the institute saw two internal strains rival factions grow,, both competing for the substantial amount of labor credits the institute was handed over.

Surgeon vs. Engineer and the Question of Ethics


The first faction for this article are the senmorteco kirurgoj (immortality surgeons). They sought to find a solution via surgery as the name indicates. They argued that since the American surgeon Charles Claude Gurthrie already grafted the head of a small mixed-breed dog onto the neck of a larger one n 1908 their side was ahead.
The other faction were the senmorteco inĝeniero (immortality engineers). Their idea was to build a new artificial body from the scratch.
Both sides were fiercely debating from the beginning but they were also cooperating on most issues. Today the distinction between both is so blurred that it doesn't exist outside of some scientific jokes. Nevertheless some people insisted to frame the whole subject as some sort of grand competition that they took part in.


The advantage the senmorteco kirurgoj enjoyed was that the crucial problem the with transplantation, the fact that surgical stitches, or sutures, leaked had already been solved. Before this breakthrough removing an organ from a body was easier than reattaching it to another, since severed blood vessels would need to be reattached in a leak proof manner. The problem of leaking sutures was solved by French-American Alexis Carrel in early nineteen hundreds. After observing the work of a lace maker, Carrel developed a new suturing procedure in which the everted ends of the blood vessels were sewn together on their outsides. This method created tight leak-proof connections with no thread in the interior of the vessel (reducing the possibility of clot formation). The technical means of transplantation now appeared possible. In 1905 Carell and Gurthie used the new suturing technique to transplant a heart from a small dog into the neck of a larger dog.

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Charles Gurthie

Despite their initial success these experiments revealed yet another barrier to successful transplants. Carrel noticed that when kidneys were transplanted withing one-and-the same animal (an autograft) both the kidney and the animal had a better chance of survival then when the kidney was transplanted into another animal (an allograft). Carrel had rediscovered a phenomenon reported in tissue grafts by the Italian surgeon Guiseppe Baronio in 1800, the atrophy of the transplanted organ more commonly referred to as "rejection". This didn't stop their research. Carrel got a Noble Prize for their work in 1912. Guthrie was left out, allegedly because of his head transplantation experiment.
An exceptional case, the prevalent attitude until the nineteen fiftieths that saw the rise of modern bio-ethics and related government oversight commissions around the world, was that of what critics call “a high minded paternalism”.
The primate of progress that is still alive in the Sovetunio. Researcher as Professor and Harvard's Surgeon in Chief, Francis D. Moore put it once believed in the "essentially ethical nature of the scientific process" itself. This meant that although subjects of research were "given a clear picture of the hazards involved and allowed to join in the discussion" nonetheless "the final decision would not be left in the hands of the patient who has not the education, the background nor dispassionate view necessary to make the decision in his own best self interest."
In the end only the virtuous character of the researcher can act as a guarantor of the integrity of the research process. Moore has to accept that he has to submit his research to ethical review committee but much like Dr. White he feels restraint and comments on this quiet publicly. In his worldview "The ethical acceptability of therapeutic innovation documented in a research application is far better attested by the nature of the scientific consultants working on the project, than by the nature of hospital panels that review cases."

One of reasons for the rise of ethic commissions in the west was the soveta pioneer Dr. Yuri Voronoy. He became interested in transplantation surgery in the 1920s, when he was a graduate student of Professor Chernyakhovsky and participated in his experiments on the kidney transplant. Under his guidance Voronoy mastered the modern methods of complex operations. On May 28, 1930 in Kharkov, the All-Union Congress of Physiologists he made the first demonstration of a kidney transplant in a dog's neck in the Sovetunio.

His next step was to perform the world's first transplantation of cadaveric kidney in humans in 1933. Unfortunately the kidney failed after a few hours of working and the patient died. This didn't discourage neither him nor his colleagues around the world. One advantage Voronoy had was that there were more than enough dead donor bodies ready. A law passed in 1924 made it a mandatory honor for every citizen of the USS to donate their dead bodies to the scientific pursuit and medical research. Since authographts were the only cases of successful organ transplantation to date, Voronoy was optimistic that kidney transplant between identical twins might work and demonstrate the practical viability of transplantation medicine. Indeed in 1935 he carried out exactly such an experiment.

The controversy that emerged outside the USS, which as Voronoy admitted he himself went through, was about the appropriateness of the removal of a healthy organ from one of the twins. So far cadavers had been the standard source for organs used in transplants. Since the norms of governing cadaver organ usage had been worked out over a hundred years earlier, the source of these organs was well established. No moral consensus existed for living donors. Dr. Voronoy's action was unprecedented and precipitated a controversy that, had nothing to do with the integrity of surgeons or of their science but with larger questions.

The controversy was twofold. Was it permissible for medical professionals to remove organs from a healthy person and was it acceptable for society as a whole to allow people to give their organs away while they are alive. Both questions raised profound issues. The deepest tenets of Western medicine the Hippocratic Oath was touched, which states the goal of all doctors is to heal and not harm the their patients. In this case in order to heal one sick patient another healthy one had to be harmed. This event is often cited as a major milestone in the movement for National Ethical Oversight for any new medical procedures or researches in many countries around the world.

In the end it was obvious that that few patients reaching with endstage kidney failure were fortunate enough to have an identical twin able and willing to provide a kidney, even less likely was it to find twins to agree to a head transplant surgery. The question was - could rejection be prevented when the graft was taken from a less closely related individual? To find the answer for that question it was necessary to understand the cause behind “rejections”. Voronoy who was interested in antibodies since the 1929 began studying immunity in transplantation of organs and tissues in animal experiments.

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(Left to right) Sergei Bryukhonenko, Anatolii Lunacharskii, Aleksei Kuliabko, and Sergei Chechulin

After years of research he formulated his theory in 1939 that organ rejection was an immune system response. Voronoy suggested that recipient's immune systems produced antigens in an attempt
to fight off the new organs, treating them as if it were an invader, sending in defensive "troops" in the form of lymphocytes and antibodies. Lymphocytes circulate through the blood infiltrating the organ, and wreaking havoc. The antibodies serve as a second line of offense, targeting the blood vessels. Voronoy hypothesized that, if the invasion metaphor was apt, drugs that forestalled or overpowered the immune system could prevent or delay rejection. In 1940 he began experimenting with cortison an immunosupressive drug that had been independently discovered by several research groups in the 1935–1940 which gave the substance different names. One of these names was „compound F“ by Oskar Wintersteiner, but it was also known as „compound Fa“ by Tadeus Reichstein and as „compound E“ by Edward Calvin Kendall. This approach looked promising, but the real major breakthrough came with the discovery of cyclosporin.

The immunosuppressive effect of cyclosporin was discovered on 6 February 1942 by Albert Hofmann an employee of the Swiss company Sandoz. Initially cyclosporin was isolated from the fungus Tolypocladium inflatum from a soil sample obtained by Sandoz scientists at Hardangervidda, in Norway in 1939. Hoffman was part of a program to purify and synthesize active constituents of fungi and plants for use as pharmaceuticals. The new drug proved to be so effective as a immunosuppressive that it is still the most wildly used drug today, even trough other drugs with similar effects have been found and synthesized. Cyclosporin opened the doors to a new era of transplantation surgery. Soveta surgeons, immediately embraced and made use of the new wonder drug.

Now the kirurgoj were getting way ahead of their inĝeniero counterparts. So far the inĝeniero hadn't done badly. At the turn of the twentieth century, Aleksei Kuliabko, a researcher at the Physiological Laboratory of the Imperial Academy of Sciences in St. Petersburg, spent several years studying physiology and pharmacology on the isolated hearts and intestines of chickens and rabbits. In February 1902, Kuliabko reported the successful revival of a rabbit heart forty-four hours after it had stopped beating. In September, after several failures, he succeeded in reviving a human heart more than twenty hours after its donor's death. Five years later, in 1907, he developed a technique of artificial circulation in a severed fish head.

Thus Sergei Bryukhonenko's famous experiments with an isolated dog head continued a long tradition of research conducted by numerous Russian and foreign scientists prior to World War I, although he happened to attract the spotlight of history. Indeed, in 1926, in the first published account of his experiments with the autojector (a primitive heart-lung machine, Bryukhonenko referred by name to five researchers who had constructed similar machines.He was explicitly emphasizing the improvements and differences of his own apparatus. Two years later, in the first detailed publication on the autojector, Bryukhonenko provided a list of his predecessors, which included no fewer than nineteen names. The autojektor composed of a pair of diaphragm linear pumps and an oxygen bubble chamber.
It could supply a canine head with oxygenated blood. The isolated head was able to show responses to external stimuli. Finally he brought a dog to clinical death (depicted mostly via a graphical plot of lung and heart activity) by draining all blood from it, left for ten minutes, then connected to the heart-lung machine described earlier. After several minutes, the heart fibrillates, then restarts a normal rhythm. Respiration likewise resumes. Those early experiments weren't perfect of course, the head survived only for approximately ten minutes and the revived to showed signs of brain damage. But the first steps in the right direction were done. The problem would later be solved by better brain cooling techniques before the surgery. If some complication happened nevertheless there was always the option of stem cell therapy to heal potential damages (2).

The device had a fascinating resemblance to the invention of the fictional Professor Douelya in the soveta novel Professor Douelya's head by Alexander Belyayev which was published in the same year. It is conceivable that the nearly simultaneous appearance of Belyayev's story and Bryukhonenko's experiments was simply a coincidence. Each, in his own field, was developing further ideas that had been explored by numerous predecessors prior to World War I. Yet, one might also suggest that the timing of Belyayev's and Bryukhonenko's works was more than coincidental. Both literary and physiological experimentation with severed heads and more generally, preoccupation with death and revival, stemmed from a particular atmosphere, the cultural milieu of mid-1920s Russia, which was at one and the same time permeated by omnipresent death and by high hopes for the future, by the losses of the Great and Class War as well as the new up and coming phenomen of Cosmism.

The invention of cyclosporin Dr. Demikhov, a member of the senmorteco kirurgoj, turned the center of attention again. He repeated Guthrie's experiments but this time with the assistance of cyclosporin. And indeed the drug worked as well on dogs as on humans. Cerberus the two headed dog became an instant star in the Sovetunio, a beloved mascot of scientific progress and a still available plush toy, much like the “Cosmonaut Dog” Laika.
However there was an obvious problem, with head transplantation, that was not existent with any other transplant. A healthy, living complete donor body was needed, which meant at present the only possible donors were brain dead patients kept alive by machines. This was the case for the first human head transplantation in 1959. The founding father of the USS Alexander Bogdanov was diagnosed with pancreatic cancer in its late stadium, a terminal and painful disease. Under other circumstances Bogdanov stated that he would simply request assisted suicide, a medical cause he championed long before he came to power. However instead of simply dieing, he preferred to be the first volunteer for a head transplantation surgery.

There were two reasons for his choice, the first and main one was that he had the faint hope that he might actually witness the construction and firing of the first space habitat into orbit. The other reason was that he wanted to set a positive example. This would he hoped nip any possible taboos that might arise against the procedure in the bud. It also ensured that the project would be as well founded as humanly possible.

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Dr. Demikhov with Cerberus

Demikhov pioneered many surgical techniques including extracorporeal hypothermic perfusion where brains are chilled to 10 degrees Celsius to allow blood flow to be interrupted for up to an hour. It took a team of thirty doctors, nurses and technicians, and chalk marks on the floor to choreograph the procedure beforehand. After a Bogdanov eventually survived the 18 hour operation, a cheer went up he smiled looking at the surgeons.
Bogdanov was left paralyzed from the neck down. There was no chance of knitting together the sectioned spinal cords and so it was mostly a technical exercise in swapping over blood supplies and sewing muscles. The procedure involved cutting through the neck at the fourth vertebra, dissecting out blood vessels and exposing the spinal cord. Metal plates would be used to mate the two halves. First the carotids and jugulars would be connected, then if all went well, the vertebral arteries. As a fall back, Demikhov had his brain cooling equipment to buy extra time during the switching of blood supplies. His main concern was not the operation itself but handling possible tissue-rejection afterward.

Bogdanov died three weeks later, but as he said in his last interview with a Pravda journalist, with the comforting knowledge that he would wake up one day. One very acute problem that remains is that the spinal cord is severed, leaving the patient as a quadriplegic.
Something two great writer and thinker had dwelt upon while coming to very different conclusions. One of them was the aforementioned Belyayev. He later explained that his book Professor Douelya's head had been to a large degree an autobiographical story. Once, a disease had kept him in a "plaster bed" for three-and-a-half years. This disease was accompanied by the paralysis of the lower half of his body. And although he could use his hands, his life during those years was reduced to the life of a "head without a body". He specifically said that "I could not feel my body at all … It was at this time that I lived through and felt everything that a head "without a body" could experience." Belyayev undeniably used his personal experiences in the literary ornamentation of the story, for instance, in describing Douelya's terrible feeling of helplessness when a large beetle flew into the lab and crawled onto his head. These years had inspired him to research deeper into scientific experiments of the time once he had become aware of them. They reminded him of his own personal trials.

Still when the choice is between certain death, or a few more years as a quadriplegic with the hope that new technology will improve ones own life, some decides to undergo the procedure and try their luck. Since assisted suicide is always a viable option in the USS, they can also always chose death anyway.

One of them would certainly have been
Bernhard Shaw. In mid March 1929, a German daily, the Berliner Tageblatt, and a US daily, the New York Times, simultaneously published a letter written by the prominent Irish dramatist and ardent anti-vivisectionist. The letter was written to answer an anonymous correspondent, who had asked Shaw's opinion about Bryukhonenko's experiments. Shaw found these experiments "frightfully interesting".

Unknowingly, Shaw envisaged a situation not dissimilar to the one depicted in Beliaev's novella, although he was far more optimistic:
"
The experiment should be tried on a scientist whose life is endangered by an incurable organic disease, say cancer of the stomach, whereby humanity is threatened with the loss of services of his brain. What is easier than to save such genius from the death bed by cutting off the head, thereby freeing the brain from disease, and keeping up artificial circulation in the arteries and veins so that the great man may continue to lecture and advise us without being impeded by body infirmities."

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Illustration of Shaw accompanying his letter in the Berliner Tageblatt

With his characteristic wit, Shaw thought about the wondrous possibilities Bryukhonenko 's work seemed to offer: "A university in which all chairs were occupied by a row of finest brains in the country with nothing but pumps attached to them – briefly, where the whole system of teaching was purely cerebral – would be [an] enormous improvement on the present state of things" He was even ready to try the procedure on himself: "I am greatly tempted to have my head cut off so that I may continue to dictate plays and books independently of any illness, without having to dress and undress or eat or do anything at all but to produce masterpieces of dramatic art and literature". His wish kind of came true, in that his head was chronically preserved after his death in 1950 in his new home of choice, the Sovetunio.

Should the technology to repair the damage to the spinal cord be developed, the possibilities of what a head transplant will accomplish are endless. Head can be transplanted, on new healthier, younger bodies allowing potentially to double the human life spans. But even if technology should reach this point, the biggest question that the Fyodorov Society had to answer was:

“Where do we get enough brain-dead people with healthy bodies, suitable for head transplantation that don't reject their new brains?”

If immortality and the dream of mass reviving the frozen ancestors shall be realized a ethically acceptable source of donor bodies had to be found. This strengthened the senmorteco inĝeniero who wanted to artificially mass produce these new bodies in factory, part for part. The man who would find a solution for this conundrum, which wasn't lying in the distant future at all, was however neither an engineer nor a surgeon.


Notes and Sources:

(1) In OTL the experiments were conducted by the US entomologist Walter Finkler in 1923.

(2) As described in the The Physiological Collective the USS finds out very early about the benefits of umbilical cord blood on brain recovery.


Krementsov, Nikolai: Off with your heads: isolated organs in early Soviet science and fiction.

 
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I changed the way nuclear power evolves ITL a little after a suggestion by Asyns. So don't wonder if there a some minor contradiction as of yet.
 
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The Belgian Bathtub
The Belgian Bathtub

The man is assigned on the globe, its place
Solidarity in attracting panic
And fight them atoms raptors
Since even to the depths firmament.
Finally each age requires time her abduction flame..

Emil Verhaeren (1902): „Les Forces tumultueuses: LA SCIENCE“


James Chadwick was awarded a Heginbottom Scholarship to study physics. The physics department of is choice was headed by Ernest Rutherford, who assigned research projects to final-year students, and instructed him to devise a means of comparing the amount of radioactive energy of two different sources.

The idea was that they could be measured in terms of the activity of 1 gram (0.035 oz) of radium, a unit of measurement which would become known as the Curie. Unfortunately, Rutherford's suggested approach was unworkable—something Chadwick knew but was afraid to tell Rutherford—so Chadwick pressed on on his own, and eventually devised the required method. The results became Chadwick's first paper, which, co-authored with Rutherford, was published in 1912. He graduated with first class honors in 1911. Having devised a means of measuring gamma radiation, Chadwick proceeded to measure the absorption of gamma rays by various gases and liquids. This time the resulting paper was published under his name only.

Chadwick was still in Germany at the start of World War I, and was interned in the Ruhleben internment camp near Berlin, where he was allowed to set up a laboratory in the stables and conduct scientific experiments using improvised materials such as radioactive toothpaste.

After his return from prison Rutherford gave Chadwick a part-time teaching position at Manchester, allowing him to continue research. In April 1919, Rutherford became director of the Cavendish Laboratory at the University of Cambridge, and Chadwick joined him there a few months later.

So far physicists had generally accepted the (incorrect) model of the atomic nucleus as composed of protons and electrons. It was known that atomic nuclei usually had about half as many positive charges than if they were composed completely of protons, and in existing models this was often explained by proposing that nuclei also contained some "nuclear electrons" to neutralize the excess charge. Thus, the nitrogen-14 nucleus would be composed of 14 protons and 7 electrons to give it a charge of +7 but a mass of 14 atomic mass units.

Rutherford was interested in detecting and measuring these „nuclear electrons“ or „neutral doublet“ and delegated this venture to his trusted associate. The particle would be uncharged but with a mass only slightly greater than the proton. Because it was uncharged there would be no electrical repulsion of the neutron as it passed through matter, so it would be much more penetrating than the proton. This would make the neutron difficult to detect.

In order to measure the mass of the neutron Chadwick came up with an ingenious solution. The method he designed involved the disintegration of a nucleus into its components by means of gamma ray bombardment. He selected a highly radioactive source that he hoped would emit gamma rays of sufficient energy to break apart a hydrogen-2 nucleus into its components proton and “neutron”. The necessary conditions for this was that he gamma ray energy of the source should be greater than the binding energy holding the nucleus together. The element which was thought to able to provide a sufficient amount of power (2,62 MeV) was the isotope Thorium C (actually Thallium-208). And indeed after separating the proton form the neutron he was able to show that the neutron was slightly heavier as expected. As a control he used Radium C (Bismuth-214) which had a gamma radiation of 1,64 MeV and so was below the threshold. It did subsequently not split the hydrogen-2 atom.

All these developments were keenly followed by Théophile Ernest de Donder a Belgian mathematician and physicist. After Chadwick publication he theorized that it should be possible to build nuclear uranium-oxide reactor.

This was a promising prospect since Belgium had just recently discovered that they were sitting on one of the largest uranium ore deposits in the world. The existence of large deposits of copper in Katanga was known for a very long time when the Belgian geologist Jules Cornet was the first scientific assessment, during an expedition in Katanga in 1891. But at the time, Katanga was too isolated for us to consider industrial exploitation of deposits identified, important as they were. surveys resumed in 1899 on the initiative of Columbia Robert Williams, a friend of Cecil Rhodes. He himself had founded the company Tanganyika Concessions Limited in order to create a joint venture to exploiting Kantaga's wealth.

London was so dominant in the UMHK because the British had half the capital and expertise in mining and metallurgical material, they controlled the main access road (the first railroad to reach the Katanga came South via Rhodesia) and they provided the labor (mainly recruited in Rhodesia).
Under the aegis of Jean Jadot, Societe Generale began to gradually reduce this British influence over the Congo's major mineral resources. To do this, it will develop other escape routes copper (Railway BCK), organize recruitment centers in Congo and federate around it different Belgian shareholders (including the government, delegating all management needs to the Societe General).

All of this meant that there were many people in important positions willing not only to listen to de Donder's proposal but also to finance it. The idea sounded deceptively simple. He would construct a tank filled with with a slurry of uranium-oxide and heavy water. Inside was a Thorium C grid which was supposed to radiate the constantly circulating slurry. De Donder hoped that not only would "neutrons" be released which collide with the uranium but also that this would lead to a chain reaction. In 1913 the German chemist Max Bodenstein first put forth the idea of chemical chain reactions. If two molecules react, not only molecules of the final reaction products are formed, but also some unstable molecules, having the property of being able to further react with the parent molecules with a far larger probability than the initial reactants.

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Anniversary Edition of the Comic "Tintin au Congo" with an updated, modern graphic style


In the new reaction, further unstable molecules are formed besides the stable products, and so on. Just during the planning phase in 1923, Danish and Dutch scientists Christian Christiansen and Hendrik Anthony Kramers , in an analysis of formation of polymers, pointed out that such a chain reaction need not start with a molecule excited by light, but could also start with two molecules colliding violently in the traditional way classically previously proposed for initiation of chemical reactions, by van' t Hoff.

The mechanism for a radioactive chain reaction was fairly simple. The "neutrons" would transmute the Uranium into hitherto unknown new elements. Since they were neutral they would not be repelled by the massive positive uranium core. At least some of these were expected to be hyper radioactive and so surely could serve the same function as the Thorium grid. Thus once the process started one only had to occasionally extract some of the new elements and replace it with some fresh uranium to keep the process going.

De Donder speculated that the extracted elements would become the new heat source to power steam turbines or be used for radiolysis. Friedrich Oskar Giesel had been the first to observe the release of dihydrogen and dioxygen from an aqueous solution of radium bromide in 1902. Marie Curie compared this phenomenon to an electrolysis without electrodes. But it was so far rather difficult to gather more precise information about the process, since the steady-state radiolysis produced only small quantities of products. The radiation sources used (seldom more than 100 mg of radium) were very weak, and moreover, the detection techniques were not very sensitive yet. Therefore, mostly qualitative observations and semi-quantitative measurements could be reported.

De Donder hoped to change that as well and to kick-start a hydrogen mass production. This in turn might allow to create more heavy water as a side effect as well. The main source of heavy water, once the prototype would be successfully tested, he hinted might become hydroelectricity generated by Katanga's dams. Even if only trace amounts should be produced, he assured his backers, they would be incredibly valuable, the new man made gold.

Once the financing was secured in February 1921 he began to acquire the necessary amounts of heavy water from Norsk Hydro, which had the monopoly at the time. The other important step was to contact, the company “Chemische Fabrik Th. Goldschmidt”.
A recommendation by Henri Buttgenbach, a director of the UMHK as well as a mineralogist and metallurgist himself. The company was the first to utilize a discovery made by Alfred Stock. He was the first to prepare metallic beryllium by electrolyzing a fused mixture of sodium and beryllium fluorides in 1912. This method made beryllium available for industrial use, as in special alloys and glasses and for making windows in X-ray tubes.

Beryllium despite the costs involved had some very desirable attributes. It is unique resistant to thermal shocks and corrosion. It was also very strong in general and non-magnetic and non-sparking something very much appreciated in case of water radiolysis and the production of oxyhydrogen gas.

Another much more important quality was then unknown to the people working on the reactor. Beryllium has a low neutron absorptiveness and high-scattering cross-section which makes it a suitable moderator and reflector in nuclear facilities. While most other metals absorb neutrons emitted during the fission of nuclear fuel, beryllium atoms only reduce the energy of such neutrons, and reflect them back into the fission zone.

In the case that the radium C should grid should not be sufficient there were plans to develop a high powered x-ray machine that should do the deed. Scientists knew that the radiation from X rays and
radium was similar, but radium was considered the „natural“ version of X rays.

Prior to 1912, X-rays were used little outside the realms of medicine and dentistry, though some X-ray pictures of metals were produced. The reason that X-rays were not used in industrial application before this date was because the X-ray tubes (the source of the X-rays) broke down under the voltages required to produce rays of satisfactory penetrating power for industrial purposes. However, that changed in 1913 when the high vacuum X-ray tubes designed by Coolidge became available although they were still operating merely in the 180–200 kV range. The emergence of megavoltage devices (megavoltage X-rays – 1 to 25 MeV ) as general technology progressed was a certainty.

Finally with all the components assembled the reactor, "Leopold's Bathtub" as it was nicknamed by the worker and press, began operation in August 1925. It did work without any other workarounds to the delight of its backer. Indeed once the first samples were extracted, new interesting, previously never seen elements were found. A new era was to begin. The real groundbreaking discovery however came in form of an old well known friend, barium.

Notes and Sources

L'Annunziata, Michael F. : Radioactivity: Introduction and History.

Rosenthal, Murray W.(2009): An Account of Oak Ridge National Laboratory’s Thirteen Nuclear Reactors.

Le Caër, Sophie (2011): Water Radiolysis: Influence of Oxide Surfaces on H2 Production under Ionizing Radiation.

Castiglione, Vera (2009): A Futurist before Futurism: Émile Verhaeren and the Technological Epic.

Linton, Otha W (1995): Medical Applications of X Ray
 
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The Fyodorov Society IV
The Fyodorov Society IV


What measure is a human?

Konstantin Skobelev was one of many employees of the “Serebrovsky Eugenic Institute” (1), the research arm of the Department of Antropotechnique.
Their main purpose was and is to identify heritable genetic trait. To do this they have an archive containing the medical and genealogical of all sovetaj citizens. They also cooperate with similar institutions around the world as well. But unlike other nation like Sweden or France (2) which still enforced a policy of forced sterilization in the seventies or in the case of France eighties, the soveta eugenics program was and is strictly voluntary.
The government simply encourages people to get counseling about the chances of potential heritable disease in their offspring. Aside form the tracing of negative traits, they record positive traits as well. People who have those, are paid very well to become sperm donors. In general it is seen as desirable for couples with bad genes to get an state sponsored artificial insemination with high quality sperm or adopt children if the mother is the bearer of the bad genes.

After all this seems to be the topic for another essay about population genetics. Well, the reason is Konstantin Skobelev, who was one of the people tasked with tracking down heritable disease and risk factors. One of the newest disease he encountered was anencephalie. The first published medical record of the disease happened in 1926 by Eduard Gamper. Children born with anencephalie were referred to as gamper creatures (Gampersche Mittelhirnwesen), or simply as gamper. Anencephaly is a cephalic disorder that results from a neural tube defect that occurs when the cephalic (head) end of the neural tube fails to close, usually between the 23rd and 26th day of pregnancy, resulting in the absence of a major portion of the brain, skull, and scalp.
Strictly speaking, the translation of the Greek term to English is "no brain" (that is, totally lacking), but it is accepted that children with this disorder are born without a forebrain, the largest part of the brain consisting mainly of the cerebral hemispheres, including the neocortex, which is responsible for higher-level cognition, i.e. thinking. The remaining brain tissue is often exposed, not covered by bone or skin. Most babies with this genetic disorder do not survive birth, however there have been notable exceptions were the skull is sufficiently developed.

While such a mutation was and is seen under most circumstances as an undesirable, Skobelev saw that it might solve the question of obtaining healthy living donor bodies for head transplants. He contacted his superior J.B.S Haldane (Head of the Eugenic Institute) who discretely contacted government officials and other trustworthy scientists. In the end it was decided to find the trigger for the mutation first before making any other arrangements. After 4 years of study they found that neural tube defects do not follow direct patterns of heredity. What they found was, that women known for taking certain medications for epilepsy and depression, specifically Valproic acid, showed a higher risk of having a child with a neural tube defect.

9kIFy.jpg


In the end what they would be doing was labeled “partial chemical abortion”. Instead of preventing the development of a human being as a whole, only the sentient part was stunned before it could develop. Thus the body would grow, but be nothing more than an empty vessel. Nevertheless most societies agree that the drive to protect and nurture one's infant is a basic human trait. Now the question was were to find volunteers, to have “gamper” born. Who would be willing to give up their child in such a manor?

The case of Alexander Luria

Alexander Luria a famous Soviet neuro- and developmental psychologist provided the answer, Chinese women. He was one of the founders of cultural-historical psychology and the leaders of the Vygotsky Circle. Luria was born in Kazan, a regional center east of Moscow, to Jewish parents. He studied at Kazan State University and graduated in 1921. He became a Doctor of Pedagogical 1937 and Medical Sciences 1943 and was appointed Professor in 1944. Throughout his career Luria worked in a wide range of scientific fields. In the Sovetunio he is best known for his work on
Synesthesia and his collaboration with the Detski Dom Laboratory (3).

His contribution to head transplant technology was his comprehensive study of the history and cultural factors influencing people's view on infanticide. His special interest in this question focused on China. In 1924, Luria met Lev Vygotsky, who would influence him greatly. Along with Alexei Nikolaevich Leontev, these three psychologists launched a project of developing a psychology of a radically new kind. This approach fused "cultural", "historical", and "instrumental" psychology and is most commonly referred to presently as cultural-historical psychology. It emphasizes the mediatory role of culture, particularly language, in the development of higher mental functions in ontogeny and phylogeny. Luria wanted to understand how culture shapes our understanding of what we regard as a person, a human being.

Infanticide the killing of an infant at the hands of a parents has been an accepted practice for disposing of unwanted or deformed children since prehistoric times. Despite human repugnance for the act, most societies, both ancient and contemporary, have practiced infanticide. Based upon both historical and contemporary data, as many as 10 to 15 percent of all babies were killed by their parents. Luria noted that infanticide had been practiced by nearly all civilizations. He concluded that infanticide must represent a common human trait, perhaps genetically encoded to promote self-survival. He split the more general term of infanticide into several sub categories. Neonaticide is generally defined as "the homicide of an infant aged one week or less." Infanticide in general usage is defined as "the homicide of a person older than one week but less than one year of age." Filicide is defined as "the homicide of a child (less than eighteen years of age) by his or her parent or stepparent."

For the purposes of this entry, the term infanticide will be used to describe the act of neonaticide. The helpless newborn has not always evoked a protective and loving response, in part because the newborn was not always believed to be human. This belief legitimized an action that under other circumstances would be referred to as murder. For example, the ancient Romans believed that the child was more like a plant than an animal until the seventh day after birth. Historically, birth was not necessarily viewed as a transition to life. Common law in England presumed that a child was born dead. According to early Jewish law, an infant was not deemed viable until it was thirty days old. During the 1950s the chief rabbi of Israel, Ben Zion Uziel, said that if an infant who was not yet thirty days old was killed, the killer could not be executed because the infant's life was still in doubt. In Japan, a child was not considered to be a human being until it released its first cry, a sign that the spirit entered its body. Scientists and ethicists continue to disagree about when life begins, fueling the moral debate surrounding abortion and infanticide. Certain parts of China in the nineteen forties and fifties did not consider newborn children fully "human", and saw "life" beginning at some point after the sixth month after birth

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Alexander Luria

Abandonment and exposure were the most common method of infanticide which aligned well with the the plans for the gamper. Abandonment represents one of the oldest methods of infanticide. History is replete with stories of babies abandoned and left to die as a result of starvation, dehydration, or animal attack. In seventeenth-century China, Jesuit missionaries reported that thousands of infants, mostly female, were deposited in the streets. One of Luria's most important findings was that mothers who killed/abandoned their children fell into two distinct groups regarding their reactions to the deed. Mothers who killed/abandoned their infants on the day of their birth (neonaticide) did not generally show signs of psychopathology while those that waited, suffered from psychological trauma. Therefore gamper could be safely taken away after birth, if it was done quickly enough.

Progress of the Gamper Program


With the blessing of China's government and as a part of the “Socialist Solidarity Program for Chinese Development” special hospitals were build alongside more conventional infrastructure. Local woman were offered a substantial monetary reward for participating in the creation of gamper. If they agreed they were monitored with the newest high tech sonographic equipment and infused with high dosages of Valproic acid. If the gamper survived the woman giving birth to them got an significant bonus, as an incentive to keep the gamper embryo safe.
The program was fairly popular in the administration and scientific circle, but had to be kept secret in fear of overzealous, "moral guardians".
Despite claims of the pro-life movement there are no indications that any participants in the program regretted having been part of the experiment. While the narrative that the initial gamper production was kept secret because the people involved knew that they were doing something evil is attractive in its simplicity, it is nevertheless wrong.

It was simply acknowledged that irrational opposition could only partially countered with rational arguments. In order for the program to survive and thrive. It was soon realized that two important things had to happen. Any new technology is flawed at the beginning, the best they could do was to learn about flaws and make mistakes in secret and reveal a fairly well established gamper production model to the world.
The second thing they needed was a success story, if one of the matured gamper helped to save the life of child for example they would be able to counter the framing of “these horrible monster experiments with babies” with the narrative of “artificially non sentient organ reservoir are part part of a life saving procedure that may save your child.”

Obviously a certain level of hysteria couldn't be avoided, but thankfully living as part of the physiological collective for more than a decade saved the public from its own fears. All these things were necessary perquisites to start things in the first place, however it was clear from the outset that these sociological conditions in China wouldn't last long since socialism unpreventable would lift up China's culture to a modern level and thus the underling working mechanism had to change in the long run. A way had to be found to inhibit the development of maternal feelings in donor women. While
it typically occurs due to pregnancy and childbirth, it may also occur between a woman and an unrelated child, such as in adoption. There are hundreds of potential factors, both physical and emotional, which can influence the mother-child bonding process. The only logical way to address this conundrum was an extensive study of mother-infant bonding disorder. Indeed our work not only helped those suffering but allowed the education of a new generation of young people having a far more differentiated outlook on what constitutes human life.


Notes and Sources:

(1) As the former “USS Eugenics Society” range of responsibility grew it became the “USS Eugenics Institute” and was renamed one last time after Serebrovsky death to honor his work.

(2) In OTL the eugenics legislation justifying Sweden’s sterilization policies was formally abolished in 1976, but only after as many as 31,000 people had been sterilized.

(3) Detski Dom ("Children's Home", a Russian term for orphanage) which opened in May 1921 in the center of Moscow and was build on the idea to apply the theories of psychoanalysis in child education.
 
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Empire of the Rising Sun: Dawn of the Nuclear Age
Empire of the Rising Sun: Dawn of the Nuclear Age

first sun ~

old mountain slowly
reborn in new light
Hatsuhinode (Fist Sunrise)

Like no other natural phenomena, the Sun has been an object of veneration in many cultures throughout human history. The oldest records of Japanese history of from Kojiki (ca. 680) and Nihon Shoki (ca. 720), tell the history of the the Sun goddess, her siblings and her descendants. According to the Nihon Shoki the Japanese Emperor, called the Tennō (heavenly sovereign), can trace his bloodline back to the goddess herself.

As part of the shōgatsu (New Year Festival), people often drive to the coast or climb a mountain so that they can see the first sunrise of the new year. This tradition also inspired the name of the Hatsuhinode Pavilion at the “The National Products Progress Exhibition” which was held in Kagoshima 1931. There Japan would unveil its industrial and scientific might to the world in form of the Taiyō hatsudenki (Solar Generator). It was more than a simple scientific breakthrough, it was meant to demonstrate that Japan had not only caught up to the West but would soon surpass it. This conveniently left out all the previous efforts that made it possible, many of them done by Western scientist.

Aston and Eddington

Since the early days of the modern scientific era, the source of the Sun's energy was a significant puzzle and it took the physicist Francis William Aston to shed some light on the mystery. He discovered in highly accurate experiments that four hydrogen atoms are heavier than one helium atom. The importance of this discovery was immediately recognized by the brilliant English astrophysicist Sir Edmund Eddington, who realized that the difference in mass meant that the sun was able to burn by converting hydrogen into helium, whereby the difference in mass of 0.7% was converted into energy according to Einstein’s famous relationship between mass and energy, E = mc2. His calculations showed that, in this way, the sun would have enough fuel for billions of years.

The theory that proton–proton fusion took place was seen as problematic however, since the temperature of the Sun was considered too low to overcome the Coulomb barrier. Eddington's answer was simple: “The helium which we handle must have been put together at some time and some place. We do not argue with the critic who urges that the stars are not hot enough for this process; we tell him to go and find a hotter place.”

He believed that something occurred that allowed for successful collisions to happened even if it was not yet clear what this something was. It would later be found out that a quantum physical phenomenon called tunneling was responsible.

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The National Products Progress Exhibition in 1931


The Discovery of Hydrogen-2

After the discovery of hydrogen-2 isotope Ernest Rutherford theorized the existence of the neutron. In particular, Rutherford considered that the disparity found between the atomic number of an atom and its atomic mass could be explained by the existence of a neutrally charged particle within the atomic nucleus. He considered the neutron to be a neutral double consisting of an electron orbiting a proton. However there was a problem with this theory. It was until now expected that hydrogen, with a measured average atomic mass very close to 1 u, the known mass of the proton, always had a nucleus composed of a single proton (a known particle), and therefore could not contain any nuclear electrons without losing its charge entirely. Thus, hydrogen should have no heavy isotopes, still hydrogen-2 somehow had been isolated, a great mystery. Many people would contribute to its solution. One of them was Yoshio Nishina, Japan's father of the artificial suns.


The Rising Sun

One of the people The men that would catapult Japan into the nuclear age were the television pioneer Kenjiro Takayanagi and the physicist Yoshio Nishina.

Takayanagi dreamed of “wireless distance vision,” which could reproduce a scene from far away ever since he saw a photo of an early television apparatus in a french magazine. Takayanagi started his research program in television at Hamamatsu Technical College (now Shizuoka University) in 1924. He himself build his first functional television prototype in December 25, 1926. This was coincidentally also the day when Emperor Taisho passed away; thus, TV in Japan began its historical journey with the start of the Showa era. Later he was offered to lead a research in the Science & Technical Research Laboratories NHK (Nippon Hōsō Kyōka) Corporation's. The NHK was Japan's first national broadcasting agency, starting with radio and later expending into the Television business.

Their worked amidst an atmosphere of intense global competition. In order to gain an advantage Takayanagi experimented with some more exotic new vacuum tube designs. In one of the design configurations, which he called the multipactor, electrons moving from one electrode to another were stopped in mid-flight with the proper application of a high-frequency magnetic field. The charge would then accumulate in the center of the tube and “form brilliant space suspended plasmoids of starlike appearance”.

Takayanagi realized that these observations might be interesting to a colleague working in the field of plasma (ionized gasses) physics. This man he had in mind was Nishina. He had plenty of experience with nuclear physics. Nishina graduated from Tokyo Imperial University in 1918 and became staff member at the Institute of Physical and Chemical Research.In 1921 he was sent to Europe for research. He visited some European universities and institutions, including Cavendish Laboratory, Georg August University of Göttingen, and University of Copenhagen. He also visited the world's first nuclear reactor in Brussel, Belgium.

In Copenhagen he did research with Niels Bohr and they became good friends. In 1929 he returned to Japan, where he endeavored to foster an environment for the study of quantum mechanics. He established the Nishina Laboratory at the Institute of Physical and Chemical Research in 1931 and invited some Western scholars to Japan including Heisenberg, Dirac and Bohr to stimulate Japanese physicists. His research was concerned with cosmic rays and particle accelerator development for which he constructed Japan's first linear accelerator in the Institute.

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Yoshio Nishina and his Taiyō hatsudenki

It didn't took long for Nishina to come up with something useful after talking with Takayanagi. The first Taiyō Hatsudenki was already build in Juli 1930. It was essentially a combination of two spherical grids placed in a vacuum chamber. The smaller, inner grid was negatively charged to as much as 100,000 volts, and placed at the center of the chamber. Then there was a second grid, positively charged just at the inside of the vacuum tank's shell.

The Hydrogen-2 gas was puffed into the chamber were it was immediately converted (ionized) to positive hydrogen-2 ions. The negative 100,000 volt grid attracted and accelerated the positive ions to such a high velocity that a few of them whizzed right through the metal mesh, and collided with other similarly accelerated deuterium nuclei at the center of the spherical grid. They were traveling so fast by then, that when they collided. The whole reaction is contained at a density sufficient to produce fusion reactions, since the charged particles are literally compressed into the required density in the central region by the process of inertial containment.

Like the sun they fused to make helium. Unfortunately, the ions often missed each other and passed on through the other side of the grid which meant the machine used a lot more energy than it made. This was also the case for the improved version of the Taiyō hatsudenki which was demonstrated at the Kagoshima exhibition. In this more advanced model the hydrogen-2 particle were first ionized and shot into the vacuum chamber by particle accelerators instead of merely dispersing them into it.

In the end the Taiyō Hatsudenki would not be the power source of the future as many people at the time hoped. The US magazine Popular Mechanics even proclaimed it would produce so much power that electricity would become too cheap to meter. Although the Taiyō hatsudenki allowed a glimpse at the nuclear energy revolution to come, its main function back then and now is that of a simple, reliable and cheap neutron source for a variety of experiments. It also layed the groundwork for Nishina magnum opus. The world's first man made hydrogen fusion explosion.


Notes and Sources

Emilio Segre (1973): Otto Stern (1888-1969): A Biographical Memoir.

Harold C. Urey (1932): A Hydrogen Isotope of Mass 2 and its concentration.

Tom Ligon (1998):The World's Simplest Fusion Reactor, And How to Make It Work.

O.Stern/M.Volmert (1919): Sind die Abweichungen der Atomgewichte von der Ganzzahligkeit durch Isotopie erklärbar?
Annalen der Physik; Volume 364, Issue 11

 
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Well, that's a panel I'd have never imagined to see in a Tintin comic book (especially that particular comic book!). :p Colonial Katanga-Wakanda ftw! :cool:
 
The following post is unchanged, with the exception of (8) and the mentioning of Kurt Blome who will play a role in future posts. (Specifically the Elder of Thule story line).
 
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