If Valkyrie succeeds, the Franks are probably saved. So there's that.
It should be noted that of the 6 million Holocaust victims, a third of them died in the last year of the war(or so I remember). So even at this stage, no Hitler would be a very good thing overall for the world in lives, especially if the Western front battles never happen and the bombing stops. Not to mention all the Hungarians, Poles, and Germans that die from the bombings and battles and uprisings. However, there is also the geopolitical standpoint, which was very different in 1944 than looking back on it 70 years later.
Time for a "how I react now, and how I would have back then" moment.
Hell, looking back on it with the benefit of hindsight, if it means saving all those lives, I'd be perfectly fine with letting Germany hang on to Silesia, going on to focus on Japan with the atom bomb in development, and letting them and the Russians destroy each other further if they feel like it. Screw Stalin, he'll be our enemy after the war anyway-if he wants unconditional surrender, he can get it himself(and mind you, Stalin was the one OPPOSED to unconditional surrender OTL). No way that will fly in late 1944 however, and I understand that-we might want them for Japan, as the atom bomb is not a given yet. I don't see FDR realizing that right away, and well he might-the Soviets are on the East, and there is no way that they will ascede to anything separate. Stalin's paranoia will be in overdrive if this all happens, and there is no way we can or will want to take on the Red Army at the time. The American people might not have loved "Uncle Joe", but they can't be turned 180 immediately like some people think.
But people aren't robots for the current propaganda either. If Germany will surrender to the Western Allies alone in late 1944, make that public, and just let the Americans advance without fighting if the Americans keep insisting on an unconditional surrender on all fronts with the current terms, the public will not react well to any American kids dying for the Soviets and their future empire if Japan is still around. Thus, I doubt that the war would last to May 1945 for the Western Allies, no matter what happens.
More immediately, the Soviets want Berlin, and they have the manpower and fighting skill to get it. I wonder how the Eastern front will go? How will they react if the Americans and British get to Berlin first as the whole German army floods to the east?