What if Europe or Africa don't colonize the New World for like 250-500 years.

Like let's assume, they have less tech, are focused on something else or discover Canada first and for some reason are made disinterested in it for a while for slow exploration.

What happens to an Americas mostly left alone by from the West, would the Eastern powers discover it?

What of the Local Ameridian powers, how are they most likely to have developed, especially as copper and bronze weapons were spreading from the Inca and Purepecha?. What would be the state of the geo-politics and states in half or a quarter millennium of continued relative isolation?.

Like It has often been said that the Polynesian discovered America, but a recent article finding Colombian Ameridian DNA in marquesas islands, polynesia which further dispersed from their and from evidence implies more than a single contact (Sweet potato names, Chicken Bones in South America), at east as early 1200 AD. Is there any chance that this can develop into something more that what is seemingly periodic trade?
And what dangers or advantages could Polynesian Pigs, Chickens and Rats bring to South America. Could a slightly more maritime coastal andean people in the Inca Empire bring any conquest benefits?

What of the Maya, they had just started recovering from their collapse, how far could day go in that short time and their neighbours in Central America have a similar story but in their case, the sort of state formation that would in OTL make states like the Miskito a thing had been underway and building up. Could the formidable OTL Miskito state still form as a somewhat great power?.

And In the Amazon. The cultures there were collapsed presumely by the introduction of tropical diseases but they before this had pretty advanced cultures and proto-states (or is it microstates?), agressive peoples uilding large tribal unions like with the Guarani (Also, in Paraguay) or the Charrua (Also in Uruguay) and in the Southern Andeas, peoples that would become a great force like the Mapuche. Just how much more expansive could their expansion have been.

What of trade, how much would trade grow in the same time.

And in North America, this period saw the formation of the Haudenoshonie, Wabanaki and Powhatan confederacies, the declined but still strong Mississippian civilizations. How would these fair with minimal (very, very indirect trade) to none at all. Would the Mississippi survive without the arrival of Eurasian plagues or are they doomed to fall to migrations, are the Haudenoshonie, Wabanaki and Powhatan destined to bring about a new era of start formation and conquest or just fizzle out unknown?.
 
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