Depends.
If Yorktown, Enterprise, and Hornet all three are lost at Midway, with fewer Japanese losses than OTL, you probably either delay or cancel the Guadalcanal operation by about six months or so. Yorktown didn't matter, but Enterprise and Hornet where heavily involved. This leaves only Saratoga and Wasp, which against a more intact Kido Butai aren't going to be enough to support the Marines.
No offense Calbear, but you really are obsessed with sticking to the same doctrine, no matter what happens. Your either really ignorant, or a really huge troll.
Rather than being insulted, which would not be an unreasonable reaction to your ending statement, lets just look at the actual facts.
The Navy ALWAYS had a Central Pacific strategy (Gilberts, Marshalls, Marianas, Iwo Jima/Volcano Islands, Ryukyus). This was the direct path to Japan, the fastest way to win the war. Even a disaster at Midway, perhaps especially a disaster at Midway, would have altered this reality.
The Southwest Pacific were always a secondary campaign for the Navy, a way to keep the pressure on the Japanese on the cheap while the fleet was built up to allow the main thrust through the Central Pacific. The Army always wanted a Southwest Pacific Campaign, mainly because without one the Army really didn't have a dog in the fight against the Japanese, but the main strategy was straight through the Central Pacific.
The U.S. needed a reliable, easier to supply place to stage the strategic air war against Japan. China was simply too hard to keep supplied with munitions, fuel and parts for the bomber offensive to have any sort of bite. That means the Marianas have to be taken even if the Southwest Pacific strategy was somehow adopted as the main thrust (something that would have certainly have happened only at the cost of King's very public resignation, with all that would have entailed). That means a major offensive strike to grab the Islands as soon as the carrier forse is of sufficient size to make it possible. The earliest that is possible in spring of 1944, the latest is late summer of 1944, hence the mid 1944 time that is consistently mentioned.
The United States was going to use the Bomb as soon as it was available, that was a given, all the hand wringing notwithstanding, unless the Japanese surrendered before that time. The earliest date the Bomb can be used is late July/early August, unless something happens that can advance the date for the Trinity test detonation. Nothing in the current POD would allow for that.
The Soviets were going to go after the Japanese three months after Germany surrendered (like him or hate him, Uncle Joe was pretty much a stickler for treaties, especially when they were in his favor). As is the case with Manhattan, nothing in the POD is going to substantially change when Germany is defeated (unless someone is ready to argue that a Japanese victory at Midway would cause the U.S. to abandon the Europe First strategy AND cut off Lend-Lease to the USSR). That again puts the date on or around August 1 for the Soviet invasion of Manchuria. The fact that both the Bomb's availability and the Soviet invasion date fall in the same timeframe is coincidence, but it is historically accurate and there is no POD that would alter that in the scenario under discussion.
If something retains the basic strategic thrust know from OTL, is strategically sound, and is also, without question, the way that the senior commanders in place wanted to run the war, keeping it as the logical result of a scenario is anything but ignorance. I will leave it to others to determine what arging against it may or may not indicate.