In 332 BC, after dealing the Achaemenids a drastic defeat at the Battle of Issus, Alexander the Great went south, to receive the submission of many Phoenician cities and to deny the Achaemenid navy a base of operations. Instead of pursuing Darius III, he traveled down the coast, with most cities submitting to him. Tyre however resisted after Alexander wanted to make a sacrifice at the city and the Tyrians refused to allow him access. What if he had not demanded the sacrifice and accepted Tyre's neutrality, or bypassed it, hoping to make it to Egypt and close off the Mediterranean to the Achaemenids, or the Tyrians decided to surrender after the defeat at Issus is more drastic? Will Darius III still raise another army? Would Alexander lose due to having to turn back to help Antipater, since the Persian navy still has a base? Or would not making an example of Tyre prolong his campaign enough that Darius takes the fight to him? Also, without the influx of Tyrian refugees and the continued importance of the city, what happens to Carthage?
 
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