Indeed, as much as I find Charles V and Philip II pretty cool guys the funky genetics they had really meant their successors weren't up to scratch.
So we could have Philip as Holy Roman Emperor; but since his son Charles was born roughly around the POD the butterflies won't affect him either. This also means that Ferdinand II isn't likely to become Emperor. And while the Habsburgs don't have Spanish gold, they do have the rich provinces of the Netherlands regardless (and are still staring at the Ottomans down south).
And an English Cardinal Henry 200+ years ahead of schedule, interesting, interesting...
Well the funky genetics only really came about due to their (Habsburg) marriage politics further down the OTL road. ITTL the Aviz-Trastamara, Tudors or Valois (or Bourbon) could end up in a similar matter as the Habsburgs IOTL.
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