Based on a couple posts stating- Timbuktu, as something that rhymes with blue; and the fact that many have pointed out that Ottoman Egypt is possibly too strong for Spain in a non-New World ATL how about this instead- Could Spain, seeing Portugal's dominance along the coast of Africa and trade routes to India decide to use Ceuta and other North African posts to push into Morocco and down to the Niger River? Several Muslim dynasties, Almohads, Almoravids, etc had extensive routes to Mali/Songhai and that area. Could Spain go looking for gold and trade goods and get rich from the Sahara/Sahel areas and then use that money in a similar, though smaller, way in Europe? And by extension if the Spanish/Portuguese personal union under Charles still occurs, could the divorce see Spain keep Portugal's West Africa coast and we see Spain monopolize West Africa with the Portuguese having Africa south of, say... Cameroon? A Treaty of Tordesillas that goes horizontally across the globe instead of vertically?