Interestingly, Denver was one of the "alternate capitals" that existed in U.S. Civil Defense of the era (no Earthquakes, hurricanes, rarely any tornadoes, not as could as might be thought (it can get into the teens at night, but it averages in the mid 40s even in the coldest months, and it isn't overly hot in the summer) while also being both centrally located and regional headquarters from most Federal Agencies).
Biggest issues with having a large population is water. and, especially, altitude.
It is fairly arid, even with snow it averages around 20 inches of rain a year, which isn't a lot. It draws from the Colorado for about half it's water, but that source has a hard cap since the flow of the Colorado is governed both by U.S. law AND International Treaty with Mexico. The allocation is sufficient (generally) for a population of around 3/4 of a million/Metro of ~3M, but 8,000,000+ in the city and 15-18M in the Metro? Not going to happen (also can't draw that much more from the Colorado, even without the Treaty with Mexico, since LA with its 3M+ (13 M metro) San Diego (1.4M/3.3 metro) and Vegas (2.3M metro) are all downstream, not to mention the Imperial Valley.
The altitude is also nothing to be underestimated. 5,100 feet may not seem that impressive compared to La Paz, Bogotá, or Mexico City, but it's about 10% higher than Katmandu and it is high enough to be a medical issue for a good number of people with headaches/dehydration/etc. being a real issue. 5K won't wreck most people, but if you are trying to get 10M in one place it could be something of an issue if there are equally good, if not superior, locations at sea level.
*It is also a pain-in-the-ass if you are cooking or making coffee (ideally 95°C/205°) or Black tea (100°C/212°F), among other things, since you can't get "boiling point" (100°C/212°F) temps unless you use a pressure cooker (thingscap out at 94.9°C/203°F).