The Eluetherian Mills (DuPont's historic powder works on the Brandywine) is more than 7 miles by road
today from the Delaware River; getting there by ship or boat from the Atlantic requires a 90-mile passage from capes Henlopen and May up Delaware Bay, then up the Delaware River to the confluence of the Delaware with the Christina River, then up the Christina to the confluence with the Brandywine (generally referred to as a creek at this point) through the
middle of the city of Wilmington (a city of more than 21,000 in 1860, which - not surprisingly - included multiple bridges over the Brandywine and the Christina) and then up the Brandywine to the Mills themselves, a 200+ acre complex that by 1840 included no less than three dams
on Brandywine Creek - so, a little dificult for the good ship
Pinafore to steam up the Brandywine or the Christina, much less overland from the Delaware.
Here's Brandywine Creek at Wilmington, for example:
Here's the website for the Hagley Museum on the mill site, which is a national historic site:
http://www.hagley.org/exhibits-powder-yards
There's also the minor problem that Delaware Bay was fortified -
Fort Delaware, on Pea Patch Island, is well south of Wilmington, as were the supporting works at what were designated as forts DuPont and Mott after the Civil War.
In addititon, there's the reality that the
Philadelphia Navy Yard was just up the river, and quite capable of both building new ships and providing a base to support ships assigned to the defense of the bay, along with - of course - the rest of the Delaware Bay shipbuilding industry, which included such minor firms as
Reaney, Son & Archbold (Chester), Neafie, Levy & Co (Philadelphia), William Cramp & Sons Ship & Engine Building Company (Philadelphia), Birely & Sons (Philadelphia), Hillman & Streaker (Philadelphia), Harlan, Hollingsworth & Co. (Wilmington), and Pusey and Jones (Wilmington), among others.
Philadelphia, of course, was the second largest city in the United States in 1860, with some 565,529 residents, and was heavily industrialized; along with shipbuilding, locomotives and railway equipment, ironworks, etc. it was also home to the Frankford and Schuykill arsenals, while the Phoenix ironworks was all of 28 miles away. Camden, just across the Delaware in New Jersey, had another 14,000, while Chester, between Philadelphia and Wilmington, had another 5,000. Obviously, militia from these communities would be available to help man the defenses of the Bay and the River, alongside the regulars/USVs/and state troops, in rotation, and could be called out en masse in time of crisis (as they were during the Gettysburg Campaign, for example). The militia establishment in Philadelphia, for example, was quite significant and predated the war by decades.
It's also worth noting the outflow of the river creates a near-constant 3 knot outflow current in the Bay, the bay itself is generally shallow, and well provided with rocks and shoals (there wasn't even a 26-foot deep channel from Philadelphia to the Bay until the middle of the Nineteenth Century, and that required significant dredging) and bounded by mudflats and marshes, and the aids to navigation on the river and bay were, of course, built and maintained (or not, in the event of war) by the United States government...
Essentially, an attempt to blockade Delaware Bay in the 1860s (much less an attempt to mount an amphibious operation up the Bay into the River, much less points north or west) is roughly equivalent of trying to blockade and/or attack up the Clyde to get at Glasgow.
And, for what its worth, none of this reality is exactly secret. Anyone who wants to can use Google maps, especially the "terrain" view and the "get directions" applet (complete with modern road mileage) to figure this sort of thing out.
The fact that so many do not, of course, says