Without the Capital at the Navigable limit on the Potomac, Alexandria VA, and Georgetown and Brandenburg MD, remain minor port towns dealing with agricultural goods, [Tobacco Road].
Quite likely, although there is probably still good reason to develop a canal going from the Potomac to the Ohio. But its probably developed a bit later than OTL.
Without the population in the area the discovery of Potomac /Virginia Gold Fields will probably be delayed till the 1850's or even later.
This Means that the Georgia Gold Fields remain the largest NAmerican Fields, till California.
[OTL in the 1840's ~ 1850's Virginia produced more Gold than Georgia]
Hmmm....wow, I wasn't even aware of the Virginia Gold Rush! I will have to weave that into the timeline. While there might not be canal building going on there, and while the general population of the USA is more spread out, the exception is Virginia. Virginia got a population boost as the go to site for a lot of Patriots escaping the South. Also, because a lot of the land was already tied up in plantations, they tended to move to the west....the first gold if wikipedia is right was found in placer deposits....actually, gold is likely to have been found in Virginia pretty close to on time ITTL if not even earlier!
Another interesting point....
assuming no major war is fought in Virginia, say by an invasion from the British South, those mines won't be damaged the way they were during the ACW, so will stay in production (though diminishing returns) longer.
?What effect will having most of Americas Gold Supply coming from BNA cause? The Mint in Georgia will be Making British Shillings & Pounds, not US Dollars and Eagles.
That would have been interesting, but I think we'll not see it for the reasons given above.