Marcus Terentius Varro dies, three days before the end of his 10 year term as president of the Senate. Sextus Appuleius is voted in as president of the Senate. The Via Julia reaches Athens in April. Ptolemy Caesar marries Claudia Marcella.
Antony and Agrippa defeat Golgius at the Battle of Media, but are defeated twice outside Ctesiphon and are forced to retreat north to Hatra in July. By October, Antony manages to defeat a Golgite army at Seleucia by bribing the Parthian commander Traxees and capturing Seleucia as a base of operations for Mesopotamia. Agrippa besieges Ctesiphon for a third time, building massive trenches around the entire city, with the intention of starving the city out. Armenia revolts against Roman rule in July.
Caesar begins his second campaign east into Carmania. This famous campaign, known today as the March to the Indus, or simply the Agmenus Indus, will secure the eastern Roman border for centuries. Scipio campaigns into northeastern Parthia, capturing Asaak and Nisa by the end of the year. Though Scipio is a far better commander than Orodes III, he can not capitalize on his gains because of the lack of man power plaguing not only his army, but the entire Roman army in Parthia. In November, Orodes III defeats Scipio in the Battle of the Atrak River, and Scipio remains in Asaak the rest of the winter.
Northern statue of the Colossi of Memnon is shattered by an earthquake in Egypt according to the Roman historian Strabo.