I lived within 10 miles of the Johnson Space Center, in an area with major oil refineries within 30 miles (Houston / Texas City / Baytown)
Depending on warning time, my father and I actually had an escape plan. One plan involved taking the sail boat to Belize, another, the desperate one, involved stealing a small light plane from a local airport (heading due south to get past the Corpus Christi refinery complexes) but if neither were possible, driving to Baytown to it would be over quick (the site of the worlds largest oil refinery). I was in college at the time, and was literally taking a course called "Nuclear War and Society", which had as a final exam question "What are the likely Soviet targets in the Houston area and the likely weapons used against them"
Texas City refinery, Baytown Refinery, Laporte refinery, Deerpark (refineries) and the Ship Channel turning basin
(we were so screwed)
It should be noted that JSC is close enough to La Porte to be knocked out from the blast and for most of it to catch fire, so it doesn't need a direct attack (and isn't critical anyway)