Well, if the Soviet Union falls - say by mid to late '42 - then the only thing in the US with a higher production priority than the B-36 would be the Manhattan Project. All the dithering about whether or not the "Hemisphere Defense Bomber" was necessary would have been immediately put paid to by Germany's victory in the East.
It'd also make for an interesting difference in the Manhattan Project in general. I wonder if it could've been sped up? The various Soviet spies in the program would now no longer have any masters to report to. Were they, in OTL, ever instructed to "slow things down" lest the US get The Bomb and use it in Europe? That wouldn't be the case here. And with an even higher priority then perhaps the availability of The Bomb might be higher.
At the least, the priority for strategic bombing aircraft would be higher. Recognizing that the bulk of those troops formerly fighting the Soviets would soon be deployed to the West Wall would give Allied planners even less enthusiasm for opening that "Second Front" across the Channel. Instead, "crushing the German war machine from above" would be preferred. The Allies had the advantage in that campaign and it consumed fewer men in prosecuting it. Best then to accelerate it rather than try to get ashore and fight with all those "new" Wehrmacht divisions "fresh" from the Eastern Front.
So, an even more vigorously prosecuted air campaign against Nazi Germany would ensue. That, along with a shift in ground forces to at least deny the Germans the fruits of the Caucuses. That would, at least, keep the Germans from getting loose in the Middle East via Persia's backdoor.
An interesting shift could be the reallocation of all those ground forces formerly slated for Overlord and have them wind up in the Pacific first. This, in recognition that storming ashore against Germany was a non-starter in '43 and '44. Wrap things up in Asia against the Japanese first and that would then allow the true concentration of forces. Drive the IJA out of China by '44 and then "liberate" Vladivostok from the rump USSR. "Recognize" the "Federal Democratic Republic of Free Russia" as being the new government of what's left of the USSR and then push west from there. This, to at least deny the Nazis from grabbing a presence in the Pacific. And to also get bases in range of bombing Germany from the east. Given the genocide that the Nazis would've been employing by that time, I don't think the Russian people would complain too much about no longer being under Soviet control.
Then, come '45 the Atomic Rain would start.
No, I don't think knocking off one or two of Germany's cities would cause the Reich to collapse and sue for peace. A sustained campaign of conventional bombing and opening cans of Instant Sunshine on appropriate targets however, would. Dropping a few Mark IIIs on Ploesti would be one initial target. Starving Germany of the resources it needed to wage its war would be the objective. So, hammering around the edges of the Reich - and thus avoiding the worst of its air defenses - would be a good approach. This, especially once the US had its Bomb production lines up and running fully. After that, the Allies could adopt a "city a day" approach to using The Bomb. And if that wasn't sufficient, they could turn the dial to "11" by adopting a "cities per day" approach.