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This question crossed by mind last night, what was the worst act of vandalism to date. Because of the pre/post 1900 split in the forum I had to pick one place so I have opted for pre 1900.
So to the question, worst act of vandalism. Note I am not taking abut masss murder. Two events come to kind that surely have to on the top of the list if not on the top
Destruction of the Library of Alexandria (assuming it was deliberate)