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Came across this bizarre entry in Wikipedia...
According to Gardner Cowles, publisher of the Des Moines Register, Willkie's visit to the Republic of China led to a bizarre consequence: Madame Chiang Kai-shek, the hugely ambitious co-ruler and First Lady of China, developed the idea that she could seduce and marry Willkie, use China's wealth to help him become president in 1944, and thus become the most powerful woman in the world. Cowles claimed that the affair was consummated in China, and that on a visit to the U.S. a few months later, she told him "If Wendell could be elected, then he and I would rule the world. I would rule the Orient and Wendell would rule the western world." He pointedly did not dismiss the possibility that Willkie, had he been nominated, might have accepted her highly improbable offer on some level.
OK - this being AH, let's go. This almost qualifies for the ASB forum, but here goes. Roosevelt is too sick to run, so the Dems put up Henry Wallace in 1944. In 1942-43, Willkie falls for Mdme Chaing, and the bloom of love cures his health problems. He is the Republican Nominee in 1944, and trounces Wallace. Then, he and Mdme Chaing come out, and he marries her.