WI Vladislaus of Bohemia and Hungary has heirs

This question has come up as an auxiliary POD in a things I'm sorta planning/writing. So, what it says. With a POD before the 16th century, Vladislaus has every chance of having a son, instead of only two daughters. His OTL situation of only having daughters is what enabled the Habsburgs to inherit Bohemia and Hungary and grow into the south-central European powerhouse that they were all the way up til 1918. Considering that his brothers also have male heirs enough to continue the Jagellionian lines in Poland and Lithuania, and assuming that these Jagellionians are more or less friendly to the Habsburg Roman Emperors, what kind of effects are there vis a vis the Baltic, Scandinavia, northern Germany, the east, the Balkans (Ottomans), and religion/church reform/Protestantism?

The effects of a Bohemia and Hungary independent of the Empire, allied strongly with Poland and Lithuania, are just massive for eastern and central Europe. Considering the non-Habsburg Hungarian kings' more tolerant attitude toward church reform, could Bohemia (with its strong Hussite/Utraquist background/history) and Hungary (with a more checkered religious past, but with Ottomans encroaching) embrace Protestantism?
 
Huh? He did have a son (Louis II) that died at Mohács.

Assuming your goal is just "Jagiellon Hungary-Bohemia" lives on: It's a ticking bomb waiting to blow, Hungary isn't the same kingdom of Matthias, the two Jagiellon monarchs consisted of one indecisive incompetent (Vladislaw) and one child that never had the chance to do anything (Louis), meanwhile the Hunyadi state apparatus was systematically destroyed by the nobility and the Hungarian Army became a backward late medieval army that was simply hopeless against the Ottomans, no mention to Bohemia were Vladislaw pretty much gave up authority even before the got Hungary. So, not a very powerful kingdom(s), at best a Austro-Polish client state struggling to survive against multiple attack from the Turks, lead by Suleiman no less, the Magnates are likely to revolt, even offer the crown to someone else if Louis tries to rein them up, and from his short reign he didn't show any remarkable skill, so... welp.

For the Reformation, nope, no way Hungary goes Protestant, unless you want the Turks to conquer the place even faster as that means Hungary is completely isolated, I mean, who is the biggest Protestant power by the mid 1500s? Denmark and Saxony beating Suleiman? It's much better to remain Catholic and in Austria and Poland's good grace than converting and receive hostility from the former and indifference from the latter.
 
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