Waterloo is in a conurbation of about half a million and is as much a tech centre as a university town. (Weird how the big university ended up in Waterloo rather than Cambridge...)
But the tech center is there directly because of the university, isn't it? And Waterloo "proper" is only 100,000 or so. How much of that population is growth because of the tech industry because of the university?
Madison, WI is 250,000 people and the state capital and I think it's still arguably a college town.