From the 1890s onwards, associations of tobacco use with cancers and vascular disease were regularly reported.
[13] In 1930,
Fritz Lickint of
Dresden,
Germany, published
[17][16] a
metaanalysis citing 167 other works to link tobacco use to lung cancer.
[16] Lickint showed that
lung cancer sufferers were likely to be smokers. He also argued that tobacco use was the best way to explain the fact that lung cancer struck men four or five times more often than women (since women smoked much less),
[17] and discussed the causal effect of smoking on cancers of the liver and bladder