WI: The Brighton Bombing was able to Dfstroy the Hotel killing all within?

For the Bomb to destroy the Hotel & kill everyone inside, Would more Explosives be required or would A different placement of the Bomb in A location of structural weakness be sufficient to bring the Building down? With the Death of P.M. & Cabinet what would be the Political fall out for the UK? Who would be the Govt? Would the Tories be able to appoint A new P.M. & Cabinet or would there be an Emergency Election? What kind of cultural impact would this have on the UK? Would there be A Military Response?
 
Would be very very hard.

When the Irgun took down the 6 story King David in 1946 they used 25 milk cans full of high explosive. It only took out one wing.

Getting enough explosive into the hotel would be a major undertaking.
 
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