One critical difference is that Tirptiz was a readily identifiable target. Standing out like a sore thumb doesn't even begin to describe it and AAA/fighter defenses were nothing like those over Berlin.
The Tirpitz does, however, give a reasonable example of the difficulty of this sort of raid. Bomber Command made three deliberate attacks with Tallboy bombs, expending a total of 68 weapons. Strike one achieved on hit well forward, causing some flooding, strike two managed ZERO hits, although one near miss was achieved, the final raid managed 2 hits (one of which was a dud) and a near miss. So you had 69 weapons expended for three, maybe four, hits and one-two near misses. That was against a warship that was 792 ft long and 118 feet wide (making a target with a 93,000+ sq. ft. footprint). The Fuhrerbunker had a total square footage of 3,000 sf, which is huge for a bomb shelter, but is a postage stamp compared to a battleship.
Hitting the bunker would be a matter of luck, and a HUGE stack of it, not skill.