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Until Isabel la catolica revived it along the lines of the Aragonese inquisition, the Castilian version was sorta defunct. It went through fits and starts of being active then falling away again.

That said, the Inquisition held a stranglehold on Spanish intellect/imagination/culture until the 18th/19th centuries, long after it had died out in the rest of Europe. What if Isabel never to revive/reorganize the Castilian Inquisition - Catholic she may be and Torquemada dinning in her ear certainly wouldn't help matters, but she was also conscious of her power as sovereign. The reason for the Castilian Inquisition's impotence before Isabel was because of quarrels between the Castilian sovereign and the pope. An alternate POD might be when Inmocent VIII ordered an investigation of abuses of the practices OTL, he was told to butt out (maybe he threatens more direly).

Fernando disliked most of Isabel's pet clerics (Torquemada least of all. He only supported the Dominican when it suited his purposes to do so), either because of their extreme orthodoxy or for personal reasons (like losing out to one and not being able to appoint his bastard son to the see of Toledo when it fell vacant).

So how does a Spain without the Inquisition look/develop?
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