First, you will actually have to deal with the fact that Santa Anna was executed by a band of traitors. Now, with this in mind, Generals Vicente Filisola and José de Urrea are going to set onto destroying the rebellion for good this time around, as both were actually more competent on fighting the Texan rebels before Santa Anna (and his gigantic ego) decided to micromanage the whole war. So, the Texians are screwed, big time, this time around.
But now, a few years down the line, with Santa Anna gone, the Mexican-American war is going to be very different.