Following up on the Meiji Inca thread, I wonder how the XIXth century colonial endeavours would unfold if the colonial powers do not have access to the Cinchona Tree and more specifically the Quinine extracted from it. It would mean that medication against Malaria would be far more limited than in OTL, would it bring the colonisation of tropical territories to a stop and thus impact greatly the economic development of colonial powers, or would it be a mere dent in the inevitable conquest of new lands?