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In 4 April 1841 President William H. Harisson died of pneumonia after a nasty cold he had contracted earlier in March (propably during his inauguration) causing a constitutional crisis about presidential succession.
Eventually after the advice of Chief Justice R. Taney Vice-President Tyler took the oath of office and became President for the remainder of Harrison's term.
How would history be affected if Harrison had survived his illness? How would his Presidency looked like? Would he be reelected?