Philip II of Spain (b.1527: d.1598) m. Maria Manuela, Princess of Portugal (b.1527: d.1545) (a), Jeanne d'Albret, III of of Navarre (b.1528: d.1572) (b), Anna of Austria (b.1549: d.1580) (c)
1a) Carlos, Prince of Asturias (b.1545: d.1568)
2b) Maria Margaret of Spain (b.1549: d.1570) m. Charles III, Duke of Lorraine (b.1543: d.1608) (a)
1a) Charles IV, Duke of Lorraine (b.1567)
2a) Marie Christine of Lorraine (b.1570)
3b) Juan III of Spain (b.1551: d.1609) m. Claude of France (b.1547: d.1595) (a)
1a) Juana of Spain (b.1569)
2a) Catarina of Spain (b.1570: d.1570)
3a) Carlos II of Spain (b.1572)
4a) Stillborn Girl (c.1573)
5a) Maria Claudia of Spain (b.1574)
6a) Pedro of Spain, King of Navarre (b.1576)
7a) Miscarriage (c.1577)
8a) Anna Carolina of Spain (b.1579)
9a) Miscarriage (c.1581)
10a) Philip of Spain (b.1583: d.1585)
11a) Miscarriage (c.1585)
4b) Stillborn Girl (c.1553)
5b) Isabella Catarina of Spain (b.1555: d.1555)
6b) Enrique of Spain, Duke of Burgundy (b.1558: d.1620) m. Sibylle of Jülich-Cleves-Berg (b.1557: d.1579) (a), Eleanor de' Medici (b.1567: d.1611) (b)
1a) Philip of Burgundy (b.1575: d.1578)
2a) Charles III, Duke of Burgundy (b.1576)
3a) Miscarriage (c.1577)
4a) Joanna of Burgundy (b.1579)
5b) Margaret of Burgundy (b.1586)
6a) Anne of Burgundy (b.1589: d.1590)
7a) John of Burgundy (b.1591)
8a) Miscarriage (c.1592)
9a) Elisabeth of Burgundy (b.1595)
10a) Eleanor of Burgundy (b.1595)
7b) Ferdinand of Spain (b.1559: d.1559)
8c) Philip of Spain (b.1573: d.1575)
9c) Carlos of Spain (b.1575: d.1576)
10c) Diego of Spain, I of Naples (b.1576: d.1629) m. Catherine Renata of Austria (b.1576: d.1599) (a), Margaret of Austria (b.1584: d.1612) (b), Anne Sophia of Brandenburg (b.1598:d.1659) (c)
1b) Miscarriage (c.1601)
2b) Stillborn Son (c.1603)
3b) Miscarriage (c.1604)
4b) Miscarriage (c.1605)
5b) Maria Theresa of Naples (b.1606: d.1606)
6b) Miscarriage (c.1608)
7b) Francesco, I of Naples (b.1611)
8b) Miscarriage (c.1612)
9c) Miscarriage (c.1619)
10c) Diego of Naples (b.1621: d.1622)
11c) Miscarriage (c.1622)
12c) Miscarriage (c.1623)
13c) Juliana of Naples (b.1625)
14c) Miscarriage (c.1626)
15c) Miscarriage (c.1627)
16c) Miscarriage (c.1628)
17c) Catherine of Naples (b.1629: d.1630)
11c) Isabella of Spain (b.1577: d.1599) m. Ferdinand II, Holy Roman Emperor (b.1578: d.1637) (a)
1a) Leopold Philip of Austria (b.1595: d.1599)
2a) Charles of Austria (b.1596: d.1597)
3a) Maria Renata of Austria (b.1597: d.1598)
4a) Ferdinand III, Holy Roman Emperor (b.1598)
5a) John Charles of Austria (b.1599: d.1600)
12c) Miscarriage (c.1578)
13c) Philip of Spain (b.1580: d.1589)