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By the 7th century, the population of Syria, Palestine and Egypt were Oriental Orthodox Christians as opposed to the Chalcedonian-leaning Eastern Roman emperors. This might have been one of the reasons why they were 'lost' to the Chalcedonian Byzantines so easily. In addition, the Byzantines' major allies in the East - Armenia, Axum and the Ghassanids - were all Oriental Orthodox Christians.

With a POD between the Council of Chalcedon and the OTL Arab conquests, how could the Byzantine Empire, including Constantinople and Asia Minor, become majority Oriental Orthodox Christians? If successful, how different would things have been?
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