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Supposing the big three are killed at the Tehran Conference in 1943. As I see it, the main immediate changes are going to be how leadership in the three affected nations change:
UK -- Eden or Atlee become PM; no serious short term changes, I don't think
USA -- Henry Wallace becomes President; if the war is still ongoing as of late 1944, I submit that he will be elected in his own right, even granting that much the Democratic establishment will grumble about it
USSR -- either there's a power struggle (which would be bad for the country and the Allies), or, more likely, a single figure emerges to take control with backing of the military and Politburo, who I expect would be Molotov
Does this have any affect on the course of the war (goals, etc)? Even if the war itself proceeds more or less as OTL, the post-war world would, I think, be very different. Any thoughts there?