In OTL, Senator Mary Landrieu was one of the people Obama was considering as his potential running mate. Ultimately he chose Joe Biden of Delaware. I don’t think Landrieu would be enough to swing Louisiana to him but who knows.
Anyway, two things:
Which Democrat becomes the lead to replace Landrieu in the 2008 election? Do they win like she did?
Does Vice President Mary Landrieu have a shot at winning the Democratic nomination in 2016?