WI: Norse contact kicks off the Colombian exchange of disease

Let's say the Vinland colony goes as OTL but unlike OTL they manage to stay just long enough for the whole pool of diseases that would come across the Atlantic with Colombus to migrate over nearly five hundred years early. For the sake of argument let's say history remains more or less as is and in the 1480s-1520s some western European explorer initiates contact.

If diseases like smallpox had been introduced in the Americas around 1000 what would that do to Native American society? Would the societies that survive the die-off have sufficient immunity and recovered population to put up enough resistance to European colonization to retain some independence?
 
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