Although it's worth noting that there would still be some English colonisation in the South. Rice, indigo (assuming similar British policy on subsidies as in OTL) and long-staple cotton can still be grown quite viably in parts of the South. Those are more limited in terms of where they can be grown - basically, warmer and coastal - but still decently profitable.
I don't think we can assume that settlement of the South would have continued anyway.
Without tobacco, the Virginia colony may well have been abandoned - it took a good 15 years (and considerable loss of lives and capital during that time) to get off the ground IOTL and that was with tobacco. Without it, things would have been very dicy. And if Virginia were abandoned, that would have had to have been hugely discouraging. This would have been the second failed colony in the region (Roanoke Island in the 1580s being the other). At that point there is no guarantee England would continue to back colonial ventures in the region at all. It might stick to the Caribbean.
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