Depends. We can go for one of the following PoDs in my opinion:
-> Catherine of Aragon has a healthy male heir-I think this should be quite easy. OTL, Henry Duke of Cornwall died suddenly at the age of 1 month for reasons unrecorded. If we have him survive, then we have a male heir, can butterfly in a couple of the later children surviving also on the grounds that Catherine dosen't do so much religious fasting, and perhaps we have a family of 2 boys and 3 girls: Henry, Edward, Mary, Elizabeth and Catherine. This solves a huge amount of problems.
-> Catherine dies during one of the pregnancies- Henry can now remarry without a divorce.
-> The Pope grants Henry's divorce-tricky, but if Charles V isn't occupying Rome, it's possible.
-> Catherine gives in and assents to the divorce-highly unlikely, she was very proud.
-> Henry meets and falls in love with a devout Catholic rather than Anne who persuades him to wait for Catherine to die before they marry. They have several illegitimate children, and when Catherine dies in the early 1530s, marry and have a legitimate male heir.
Main effects are that without the monastary money, and the threat of invasion, the English navy develops later, but we might see earlier English colonies as protestants leave for America.