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WI potatoes never evolved the way we know them?
Say the potato plant manages to make itself rather toxic- some native animals would stand a chance of still eating it but humans would just poison themselves and become rather ill.
Don't laugh here, I know some of you are. Though not immediately obvious to some this is is a BIG DEAL.
Obviously the inca and related civilizations will never develop...but greater still would be the impact on the rest of the world even discounting the butterflies from this.
Without the potato spreading to Europe history would go very differently.